亞氨基取代的苯乙酰胺、它們的制備及含有它們的殺真菌劑的制作方法

專利名稱：亞氨基取代的苯乙酰胺、它們的制備及含有它們的殺真菌劑的制作方法
技術(shù)領(lǐng)域：
本發(fā)明涉及下式所示取代的苯乙酰胺 式中各取代基的意義如下Y為氧原子或基團(tuán)NR6；Z1和Z2相互獨(dú)立地為氫原子、鹵原子、烷基、鏈烯基、鏈炔基、烷氧基、鏈烯基氧基、鹵代烷基、鹵代烷氧基、鹵代鏈烯基氧基、氰基或硝基；R1為氫原子、烷基、鹵代烷基或芳基；R2為氫原子，或者為取代或未取代的烷基、鏈烯基、鏈炔基、環(huán)烷基、雜芳基烷基、雜環(huán)基、環(huán)烯基、芳烷基、芳基、雜芳基、芳基鏈烯基、雜芳基鏈烯基、芳氧基烷基、雜芳氧基烷基、?；?、芳基羰基、雜芳基羰基或烷氧羰基R3、R4、R5和R6相互獨(dú)立地為氫原子或烷基；或者R6和R2同與它們相連的氮原子一起形成環(huán)。
本發(fā)明還涉及制備這些化合物的方法和中間體。
已知可使用亞氨基取代的苯乙酸衍生物作殺真菌劑(EP499823)。但是在許多情況下它們的功效不能令人滿意。
因此，本發(fā)明目的是改進(jìn)了功效和更廣譜的化合物。
本申請(qǐng)人發(fā)現(xiàn)了上述定義的化合物I。
還發(fā)現(xiàn)式I所示化合物具有良好的殺昆蟲、殺線蟲和殺螨活性。殺真菌活性是優(yōu)選的。
考慮到它們的防治有害真菌的生理活性，適宜的化合物I例如是其中的取代基具有如下意義的化合物Z1和Z2是氫原子，鹵原子如氟、氯、溴和碘原子，或者例如甲基、甲氧基、氰基和硝基；R3、R4、R5和R6是氫原子，C1—C6烷基，如甲基、乙基、丙基、1—甲基乙基、丁基、1—甲基丙基、2—甲基丙基、1，1—二甲基乙基、戊基、1—甲基丁基、2—甲基丁基、3—甲基丁基、2，2—二甲基丙基、1—乙基丙基、己基、1，1—二甲基丙基、1，2—二甲基丙基、1—甲基苯基、2—甲基戊基、3—甲基戊基、4—甲基戊基、1，1—二甲基丁基、1，2—二甲基丁基、1，3—二甲基丁基、2，2—二甲基丁基、2，3—二甲基丁基、3，3—二甲基丁基、1—乙基丁基、2—乙基丁基、1，1，2—三甲基丙基、1，2，2—三甲基丙基、1—乙基—1—甲基丙基和1—乙基—2—甲基丙基；R1是*氫原子，*C1—C4烷基，如甲基、乙基、丙基、1—甲基乙基、丁基、1—甲基丙基、2—甲基丙基和1，1—二甲基乙基，*C1—C4鹵代烷基，特別是C1—C2鹵代烷基，如氯甲基、二氯甲基、三氯甲基、氟甲基、二氟甲基、三氟甲基、一氯一氟甲基、二氯一氟甲基、一氯二氟甲基、1—氟乙基、2—氟乙基、2，2—二氟乙基、2，2，2—三氟乙基、2—氯—2—氟乙基、2—氯—2，2—二氟乙基、2，2—二氯—2—氟乙基、2，2，2—三氟乙基和五氟乙基，*未取代或取代的芳基，如苯基、萘基和蒽基，優(yōu)選苯基和萘基，特別是苯基；R2是*氫原子，如上所述的C1—C4烷基，*未取代或取代的C3—C15鏈烯基、特別是C3—C6鏈烯基，如2—丙烯基、2—丁烯基、3—丁烯基、1—甲基—2—丙烯基、2—甲基—2—丙烯基、2—戊烯基、3—戊烯基、4—戊烯基、1—甲基—2—丁烯基、2—甲基—2—丁烯基、3—甲基—2—丁烯基、1—甲基—3—丁烯基、2—甲基—3—丁烯基、3—甲基—3—丁烯基、1，1—二甲基—2—丙烯基、1，2—二甲基—2—丙烯基、1—乙基—2—丙烯基、2—己烯基、3—己烯基、4—己烯基、5—己烯基、1—甲基—2—戊烯基、2—甲基—2—戊烯基、3—甲基—2—戊烯基、4—甲基—2—戊烯基、1—甲基—2—戊烯基、2—甲基—3—戊烯基、3—甲基—3—戊烯基、4—甲基—3—戊烯基、1—甲基—4—戊烯基、2—甲基—4—戊烯基、3—甲基—4—戊烯基、4—甲基—4—戊烯基、1，1—二甲基—2—丁烯基、1，1—二甲基—3—丁烯基、1，2—二甲基—2—丁烯基、1，2—二甲基—3—丁烯基、1，3—二甲基—2—丁烯基、1，3—二甲基—3—丁烯基、2，2—二甲基—3—丁烯基、2，3—二甲基—2—丁烯基、2，3—二甲基—3—丁烯基、3，3—二甲基—2—丁烯基、1—乙基—2—丁烯基、1—乙基—3—丁烯基、2—乙基—2—丁烯基、2—乙基—3—丁烯基、1，1，2—三甲基—2—丙烯基、1—乙基—1—甲基—2—丙烯基和1—乙基—2—甲基—2—丙烯基，*未取代的或取代的C3—C8鏈炔基，如2—丙炔基、2—丁炔基、3—丁炔基、1—甲基—2—丙炔基、2—戊炔基、3—戊炔基、4—戊炔基、1—甲基—2—丁炔基、1—甲基—3—丁炔基、2—甲基—3—丁炔基、1，1—二甲基—2—丙炔基、1—乙基—2—丙炔基、2—己炔基、3—己炔基、4—己炔基、5—己炔基、1—甲基—2—戊炔基、1—甲基—3—戊炔基、1—甲基—4—戊炔基、2—甲基—3—戊炔基、2—甲基—4—戊炔基、3—甲基—4—戊炔基、4—甲基—2—戊炔基、1，1—二甲基—2—丁炔基、1，1—二甲基—3—丁炔基、1，2—二甲基—3—丁炔基、2，2—二甲基—3—丁炔基、1—乙基—2—丁炔基、1—乙基—3—丁炔基和1—乙基—1—甲基—2—丙炔基，*未取代的或取代的C3—C8環(huán)烷基，如環(huán)丙基、環(huán)丁基、環(huán)戊基、環(huán)己基、環(huán)庚基和環(huán)辛基，*(C1—C4烷氧基)羰基—(C1—C4烷基)，如甲氧羰基甲基、乙氧羰基甲基、丙氧羰基甲基、1—甲基乙氧羰基甲基、丁氧羰基甲基、1—甲基丙氧羰基甲基和1，1—二甲基乙氧羰基甲基，*未取代或取代的C5—C8環(huán)烯基，如環(huán)戊—1—烯基、環(huán)戊—2—烯基、環(huán)戊—3—烯基、環(huán)己—1—烯基、環(huán)己—2—烯基、環(huán)己—3—烯基、環(huán)庚—1—烯基、環(huán)庚—2—烯基、環(huán)庚—3—烯基、環(huán)庚—4—烯基、環(huán)己—2—烯基、環(huán)己—3—烯基、環(huán)庚—l—烯基、環(huán)庚—2—烯基、環(huán)庚—3—烯基、環(huán)庚—4—烯基、環(huán)辛—1—烯基、環(huán)辛—2—烯基、環(huán)辛—3—烯基和環(huán)辛—1—烯基，*未取代或取代的芳基(如苯基、萘基、蒽基)，*未取代或取代的芳基—(C1—C4)烷基(如苯甲基、1—苯乙基、2—苯乙基、1—苯丙基、2—苯丙基、3—苯丙基、2—甲基—3—苯丙基、2—甲基—2—苯丙基、4—苯丁基)，*未取代或取代的?；?，例如(C1—C4烷基)羰基，如乙?；⒈；⒍□；?，苯乙?；吐纫阴；?未取代或取代的芳基羰基，如苯甲酰基和2，4—二氯苯甲?；?，*未取代或取代的雜芳基羰基，如2—吡啶基羰基，*未取代或取代的芳基—(C1—C4)鏈烯基(如苯基—1—乙烯基、2—苯基—1—丙烯基、2，2—二苯基乙烯基、1—苯基—1—丙烯—2—基和1—苯基丁烯基)，*未取代或取代的芳氧基—(C1—C4)烷基，如苯氧甲基、苯氧乙基和苯氧丙基，*未取代或取代的雜芳基(如2—吡啶基、3—吡啶基、4—吡啶基、3—噠嗪基、4—噠嗪基、1—吡唑基、3—吡唑基、4—吡唑基、2—吡嗪基、2—嘧啶基、4—嘧啶基、5—嘧啶基、1—吲唑基、3—吲唑基、2—呋喃基、3—呋喃基、1—吡咯基、2—吡咯基、3—吡咯基、2—噻吩基、3—噻吩基、1—咪唑基、2—咪唑基、4—咪唑基、5—咪唑基、2—異吲哚基、1—吲哚基、1—吲唑基、1，2—苯并噻唑—3—基、1，3—苯并噻唑—2—基、3—異噁唑基、4—異噁唑基、5—異噁唑基、3—異噻唑基、4—異噻唑基、5—異噻唑基、1，2—苯并噁唑—3—基、1，3—苯并噁唑—2—基、1，2，4—三唑基、1，3，4—三唑基、7—purinyl、2—喹啉基、3—喹啉基、4—喹啉基、1—異喹啉基、3—異喹啉基、4—異喹啉基、2—苯并呋喃基、3—苯并呋喃基、1—異苯并呋喃基、1，2，4—三嗪—3—基和1，3，5—三嗪—2—基)，*未取代或取代的雜芳基—(C1—C4)烷基(如2—吡啶基甲基、3—吡啶基甲基)，*未取代或取代的雜芳基—(C2—C4)鏈烯基(如2’—呋喃基—2—乙烯基、2’—噻吩基—2—乙烯基、3’—吡啶基—2—乙烯基)，*未取代或取代的雜環(huán)基(如環(huán)氧乙烷基、1—氮雜環(huán)丙烷基、1—氮雜環(huán)丁烷基、1—吡咯烷基、2—四氫呋喃基、2—四氫吡喃基、3—四氫吡喃基、1—哌啶基、1—嗎啉基、1—哌嗪基、1，3—二噁烷基、3—四氫噻喃基)。
除了氫原子外，上述“未取代的或取代的”所指的取代基例如為下列基團(tuán)鹵原子，如氟、氯、溴和碘原子；C1—C6烷基，如甲基、乙基、丙基、1—甲基乙基、丁基、1—甲基丙基、2—甲基丙基、1，1—二甲基乙基、戊基、1—甲基丁基、2—甲基丁基、3—甲基丁基、2，2—二甲基丙基、1—乙基丙基、己基、1，1—二甲基丙基、1，2—二甲基丙基、1—甲基戊基、2—甲基戊基、3—甲基戊基、4—甲基戊基、1，1—二甲基丁基、1，2—二甲基丁基、1，3—二甲基丁基、2，2—二甲基丁基、2，3—二甲基丁基、3，3—二甲基丁基、1—乙基丁基、2—乙基丁基、1，1，2—三甲基丙基、1，2，2—三甲基丙基、1—乙基—1—甲基丙基和1—乙基—2—甲基丙基；C1—C6烷氧基，如甲氧基、乙氧基、丙氧基、1—甲基乙氧基、丁氧基、1—甲基丙氧基、2—甲基丙氧基、1，1—二甲基乙氧基、戊氧基、1—甲基丁氧基、3—甲基丁氧基、1，1-甲基丙氧基、1，2-二甲基丙氧基、2，2—二甲基丙氧基、1—乙基丙氧基、己氧基、1—甲基戊氧基、2—甲基戊氧基、3—甲基戊氧基、4—甲基戊氧基、1，1—二甲基丁氧基、1，2—二甲基丁氧基、1，3—二甲基丁氧基、2，2—二甲基丁氧基、2，3—二甲基丁氧基、3，3—二甲基丁氧基、1—乙基丁氧基、2—乙基丁氧基、1，1，2—三甲基丙氧基、1，2，2—三甲基丙氧基、1—乙基—1—甲基丙氧基和1—乙基—2—甲基丙氧基；C1—C6烷硫基，如甲硫基、乙硫基、丙硫基、1—甲基乙硫基、丁硫基、1—甲基丙硫基、2—甲基丙硫基、1，1—二甲基乙硫基、戊硫基、1—甲基丁硫基、2—甲基丁硫基、3—甲基丁硫基、2，2—二甲基丙硫基、1—乙基丙硫基、己硫基、1，1—二甲基丙硫基、1，2—二甲基丙硫基、1—甲基戊硫基、2—甲基戊硫基、3—甲基戊硫基、4—甲基戊硫基、1，1—二甲基丁硫基、1，2—二甲基丁硫基、1，3—二甲基丁硫基、2，2—二甲基丁硫基、2，3—二甲基丁硫基、3，3—二甲基丁硫基、1—乙基丁硫基、2—乙基丁硫基、1，1，2—三甲基丙硫基、1，2，2—三甲基丙硫基、1—乙基—1—甲基丙硫基和1—乙基—2—甲基丙硫基；C2—C4鹵代烷基、特別是C1—C2鹵代烷基，如氯甲基、二氯甲基、三氯甲基、氟甲基、二氟甲基、三氟甲基、三氟甲基、氯氟甲基、二氯一氟甲基、一氯二氟甲基、1—氟乙基、2—氟乙基、2，2—二氟乙基、2，2，2—三氟乙基、2—氯—2—氟乙基、2—氯—2，2—二氟乙基、2，2—二氯—2—氟乙基、2，2，2—三氯乙基和五氟乙基；C1—C4鹵代烷氧基、特別是C1—C2鹵代烷氧基，如氯甲氧基、二氯甲氧基、三氯甲氧基、氟甲氧基、二氟甲氧基、三氟甲氧基、氯氟甲氧基、二氯一氟甲氧基、一氯二氟甲氧基、1—氟乙氧基、2—氟乙氧基、2，2—二氟乙氧基、2，2，2—三氟乙氧基、2—氯—2—氟乙氧基、2—氯—2，2—二氟乙氧基、2，2—二氯—2—氟乙氧基、2，2，2—三氯乙氧基和五氟乙氧基；C2—C6鏈烯基氧基，如乙烯基氧基、1—丙烯基氧基、2—丙烯基氧基、1—甲基乙烯基氧基、1—丁烯基氧基、2—丁烯基氧基、3—丁烯基氧基、1—甲基—1—丙烯基氧基、2—甲基—1—丙烯基氧基、1—甲基—2—丙烯基氧基、2—甲基—2—丙烯基氧基、1—戊烯基氧基、2—戊烯基氧基、3—戊烯基氧基、4—戊烯基氧基、1—甲基—1—丁烯基氧基、2—甲基—1—丁烯基氧基、3—甲基—1—丁烯基氧基、1—甲基—2—丁烯基氧基、2—甲基—2—丁烯基氧基、3—甲基—2—丁烯基氧基、1—甲基—3—丁烯基氧基、2—甲基—3—丁烯基氧基、3—甲基—3—丁烯基氧基、1，1—二甲基—2—丙烯基氧基、1，2—二甲基—1—丙烯基氧基、1，2—二甲基—2—丙烯基氧基、1—乙基—1—丙烯基氧基、1—乙基—2—丙烯基氧基、1—己烯基氧基、2—己烯基氧基、3—己烯基氧基、4—己烯基氧基、5—己烯基氧基、1—甲基—1—戊烯基氧基、2—甲基—1—戊烯基氧基、3—甲基—1—戊烯基氧基、4—甲基—1—戊烯基氧基、1—甲基—2—戊烯基氧基、2—甲基—2—戊烯基氧基、3—甲基—2—戊烯基氧基、4—甲基—2—戊烯基氧基、1—甲基—3—戊烯基氧基、2—甲基—3—戊烯基氧基、3—甲基—3—戊烯基氧基、4—甲基—2—戊烯基氧基、1—甲基—4—戊烯基氧基、2—甲基—4—戊烯基氧基、3—甲基—4—戊烯基氧基、4—甲基—4—戊烯基氧基、1，1—二甲基—2—丁烯基氧基、1，1—二甲基—3—丁烯基氧基；氰基，氰氧基，氰硫基，硝基，氨基，羥基，羧基；二(C1—C6烷基)氨基、特別是二(C1—C4烷基)氨基，如N，N—二甲基氨基、N，N—二乙基氨基、N，N—二丙基氨基、N，N—二(1—甲基乙基)氨基、N，N—二丁基氨基、N，N—二(1—甲基丙基)氨基、N，N—二(2—甲基丙基)氨基、N，N—二(1，1—二甲基乙基)氨基、N—乙基—N—甲基—氨基、N—甲基—N—丙基氨基、N—甲基—N—(1—甲基乙基)氨基、N—丁基—N—甲基氨基、N—甲基—N—(1—甲基丙基)氨基、N—甲基—N—(2—甲基丙基)氨基、N—(1，1—二甲基乙基)—N—甲基氨基、N—乙基—N—丙基氨基、N—乙基—N—(1—甲基乙基)氨基、N—丁基—N—乙基氨基、N—乙基—N—(1—甲基丙基)氨基、N—乙基—N—(2—甲基丙基)氨基、N—(1—甲基丙基)—N—丙基氨基、N—(2—甲基丙基)—N—丙基氨基、N—(1，1—二甲基乙基)—N—丙基氨基、N—丁基—N—(1—甲基乙基)氨基、N—(1—甲基乙基)—N—(1—甲基丙基)氨基、N—(1—甲基乙基)—N—(2—甲基丙基)氨基、N—(1，1—二甲基乙基)—N—(1—甲基乙基)氨基、N—丁基—N—(1—甲基丙基)氨基、N—丁基—N—(2—甲基丙基)氨基、N—丁基—N—(1，1—二甲基乙基)氨基、N—(1—甲基丙基)—N—(2—甲基丙基)氨基、N—(1，1—二甲基乙基)—N—(1—甲基丙基)氨基和N—(1，1—二甲基乙基)—N—(2—甲基丙基)氨基；苯基、苯氧基、苯硫基和苯氨基，苯環(huán)上可帶有1—5個(gè)如上所述的鹵原子，和/或1—5個(gè)如上所述的C1—C6烷氧基，和/或1—5個(gè)如上所述的C1—C6烷硫基，和/或1—5個(gè)如上所述的C1—C4鹵代烷基，和/或1—4個(gè)C1—C6烷氧亞氨基甲基(如甲氧亞氨基甲基、乙氧亞氨基甲基、正丙氧亞氨基甲基、正丁氧亞氨基甲基、正戊氧亞氨基甲基、正己氧亞氨基甲基、烯丙氧亞氨基甲基、苯甲氧亞氨基甲基、異丙氧亞氨基甲基、異丁氧亞氨基甲基和叔丁氧亞氨基甲基)，和/或1—4個(gè)C1—C6烷氧亞氨基乙基(如甲氧亞氨基乙基、乙氧亞氨基—1—乙基、正丙氧亞氨基—1—乙基、正丁氧亞氨基—1—乙基、正戊氧亞氨基—1—乙基、正己氧亞氨基—1—乙基、烯丙氧亞氨基—1—乙基、苯甲氧亞氨基—1—乙基)，和/或苯基、苯氧基及苯甲氧基，和/或C1—C4烷基亞氨基甲基(如甲基亞氨基甲基及乙基亞氨基甲基)，和/或1—4個(gè)C3—C6環(huán)烷基(如環(huán)丙基、環(huán)丁基、環(huán)戊基及環(huán)己基)。
在制備時(shí)，由于C＝C或C＝N雙鍵的存在下，可得到式I所示新穎化合物的E/Z異構(gòu)體混合物。用結(jié)晶結(jié)或色譜法可將它們拆分。它們的單個(gè)異構(gòu)體及它們的混合物都在本發(fā)明范圍內(nèi)，都可用作殺真菌劑。
特別優(yōu)選式中的取代基如下定義的式I化合物Y是氧原子或基團(tuán)N—R6；Z1和Z2相互獨(dú)立地為氫原子、甲基、甲氧基、氯原子、溴原子或三氟甲基；R1是氫原子、甲基或三氟甲基；R2是氫原子，或者未取代或取代的烷基、鏈烯基、鏈炔基、環(huán)烷基、芳基烷基、雜芳基烷基、芳氧基烷基或雜芳氧基烷基；以及R3、R4、R5和R6是氫原子、甲基或乙基。
此外，還優(yōu)選式中的取代基如下定義的式I化合物Y是氧原子，Z1和Z2是氫原子，R3和R4是甲基，R5是氫原子；以及R1是氫原子或甲基；以及R1是氫原子、烷基、烯丙基、炔丙基、芳烷基、雜芳基烷基、芳氧基烷基或雜芳氧基烷基。
此外，還優(yōu)選式中的R1是氫原子和R2是3—三氟甲基苯甲基的式I化合物。
還優(yōu)選式中的R1是甲基和R2是3—三氟甲基苯甲基的式I化合物。
權(quán)利要求1所要求的式I化合物例如可按方案1所示路線制備(Z1和Z2表示氫原子)。
方案1
式I化合物例如可從式II所示酯(其制備公開于EP499 823中)、由II與氨或式III所示的胺反應(yīng)制備。
式中的R4為H的式I化合物可由式IV所示羰基化合物(其中的R1＝H的制備參見EP393 428，R1不是氫的制備參見EP499823)與伯胺V反應(yīng)，得到環(huán)狀醛縮一胺VI，它與其醛或酮形式VII呈動(dòng)態(tài)平衡，并以羰基化合物VII的形式與羥胺或肼的衍生物VIII或其酸加成鹽反應(yīng)，形成式I化合物(式中的R4＝烷基和R5＝H)。
式VI或VII中間體還可以從化合物X(方案2)(它可按已知方法由苯基乙醛酸酯與烷氧基胺鹽酸鹽和伯胺反應(yīng)來制備)制備，首先將X二次金屬化成XI，為此使用烷基金屬如丁基鋰(J.Org.Chem.29(1964)，853)或金屬胺化物如二異丙胺化鎂(EP418 013)；并使XI與羧酸衍生物XII(如羧酰氯、酸酐或酯)反應(yīng)，或用醛XIII將XI轉(zhuǎn)化成醇XIV、然后按已知方法氧化，制得羰基化合物VII(或其環(huán)狀形式VI)。
方案2
式VIII(Y＝O)所示羥胺衍生物或是已知的，或可根據(jù)類似于Houben—Weyl X/1，pp.1192和1183的已知方法制備。
式VIII(Y＝NR6)所示肼衍生物或是已知的，或可根據(jù)類似于Houben—Weyl X/2，pp.271,280和740的已知方法制備。
胺(III和V)、苯基乙醛酸酯(IX)、羧酸衍生物(XII)和醛(XIII)是常見的已知化合物。
下列方法和實(shí)施例用于說明制備本發(fā)明的新穎活性化合物及其中間體的方法。
實(shí)施例11—羥基—2—甲基—4—甲氧亞氨基—1，2，3，4—四氫異喹啉—3—酮(方案1中的式VI化合物，R1＝H、R3＝R4＝CH3)的制備將11.0g(50mmol)式IV所示醛[(R1＝H，R3＝R7＝CH3)，其制備參見EP393 428)]溶于200ml THF中，并與10ml濃度為40％的甲胺(112mmol)水溶液一起在25℃攪拌30分鐘。形成的化合物VI部分沉淀，將沉淀物抽濾分離，用醚洗滌并干燥。將母液濃縮又得到一些產(chǎn)品，用二異丙基醚處理殘余物，抽濾。共得到9.0g無色晶體，產(chǎn)率82％，m.p.116—168℃。1H-NMR(CDCl3，D值)2.2-2.5(br，OH)，3.26(s，3H，NCH3)；4.06(s，3H，OCH3)；4.06(s，3H，OCH3)；5.71(s，1H，CH-OH)；7.2-7.5(m，3H)和8.41(dd，1H；芳烴質(zhì)子)13C-NMR(CDCl3D值)33.o(q，NCH3)；64.0(q，OCH3)；82.6(d，HC-OH；125.0(s，C-C＝N)；127.6/128.7/130.2/130.6(4d，三級(jí)芳香C)；135.6(s，C-CHOH)；141.6(s，C＝N)；161.4(s，C＝O)IR(KBr，v in cm-1)3295，1648，1576，1021，765.
b)2—(O—3—溴苯甲基肟乙基)—α—甲氧亞氨基—N—甲基苯乙酰胺(表1中的化合物58)的制備半1.7g(7.7mmol)根據(jù)a)制備的醛縮一胺(VI)與2.3g(7.7mmol)3—溴苯甲氧基胺鹽酸鹽(VIII)(R2—Y＝3—BrC6H4CH2—O)一起在150ml THF中回流1小時(shí)。冷卻后，反應(yīng)混合物用飽和氯化鈉溶液洗滌2次，用硫酸鎂干燥，并濃縮。用環(huán)己烷/乙酸乙酯(90∶10—70∶30)作洗脫液，將殘余油狀物在硅膠上層析，并將油狀產(chǎn)物用二異丙基醚結(jié)晶，得到1.1g近于無色的晶體，并率38％，m.p.103—105℃。1H-NMR(CDCl3，D值)2.88(d，3H，NCH3)；3.90(s，3H，OCH3)；5.10(s，2H，OCH2)；6.73(br 2，1H，NH)；7.1-7.8(m，8H，芳烴質(zhì)于)7.94(s，1H，CH＝N－O).
實(shí)施例22—(O—3—甲基苯甲基肟甲基)—α—甲氧亞氨基—N—甲基苯乙酰胺(表1中的化合物36)的制備將13.6g(40mmol)2—(O—3—甲基苯甲基肟甲基)—α—甲氧亞氨基苯乙酸甲酯(其制備參見EP499 823)溶于100ml四氫呋喃中，向其中加入12ml濃度為40％的甲胺水溶液(150mmol CH3NH2)，并將該混合物在40℃攪拌7小時(shí)。
使其冷卻至25℃，加入乙醚，使其分相，有機(jī)相用水洗滌，用硫酸鈉干燥，并真空濃縮。得到13.0g黃色油狀物，產(chǎn)率96％。
IR(γ，cm-1)1699，1527，1411，1035，980，785，756。
用與上述相同的方法，制備下列表中的活性化合物
表1 化合物編號(hào).R2物化數(shù)據(jù)[M.p.(℃)；IR(cm-1)NMR(ppm)]1H2CH3M.p.98℃3CH3CH24CH3CH2CH25CH2＝CH-CH26CH2＝C(Cl)-CH2NMR(δ)＝2.94(d，3H)，3.97(s，3H)，4.68(s，2H)，5.43(d，2H)，6.8(s，1H)，7.2-8.0(m，5H)7CH3-CH＝CH-CH(CH3)8CH2＝C(CH3)-CH29HC＝C-CH210 CH3-O-CH2-CH211 C2H5-O-CH2-CH212 Cl-CH2-CH213 Cyclo-C3H5-CH214 CH3-CH＝CH-CH215 CH2＝CH-CH2-CH216 CH3-C≡C-CH217 CH3CH2-C≡C-CH218 CH3-(CH2)319 CH3-(CH2)420 (CH3)3CM.p.94℃21 環(huán)-C6H1122 2-CH3-環(huán)-C6H1023 C6H5-CH2M.p.116-119℃24 2-F-C6H4-CH225 3-F-C6H4-CH226 4-F-C6H4-CH227 2-Cl-C6H4-CH2
283-C1-C6H4-CH2IR1667，1527，1028，978，787，700294-Cl-C6H4-CH2M.p.142℃30 2，3-Cl2-C6H3-CH231 2，4-Cl2-C6H3-CH232 3，5-Cl2-C6H3-CH2M.p.92℃33 2，6-Cl2-C6H3-CH234 3，4-Cl2-C6H3-CH2NMR2.9(d，3H)，3.93(s，3H)，5.1(s，2H)，6.8(s，2H)and 7.2-8.0(m，3H)352-CH3-C6H4-CH2IR1667，1526，1036，980，747363-CH3-C6H4-CH2IR1669，1527，1411，1035，980，785，756374-CH3-C6H4-CH21661，1522，1492，1087，103538 2，3-(CH3)2-C6H3-CH239 2，4-(CH3)2-C6H3-CH240 2，5-(CH3)2-C6H3-CH241 3，4-(CH3)2-C6H3-CH242 3，5-(CH3)2-C6H3-CH243 4，5-(CH3)2-C6H3-CH244 2，3，4-(CH3)3-C6H2-CH245 2，4，5-(CH3)3-C6H2-CH246 2，4，6-(CH3)3-C6H2-CH247 2，3，6-(CH3)3-C6H2-CH2482-CF3-C6H4-CH2493-CF3-C5H4-CH2M.p.166-168℃504-CF3-C6H4-CH2512-CH3-3-CF3-C6H3-CH2522-CH3-4-CF3-C6H3-CH2532-CF3-3-CH3-C6H3-CH3542-CF3-4-CH3-C6H3-CH2552-CF3-5-CH3-C6H3-CH2562-CH3-5-CF3-C6H3-CH2572-Br-C6H4-CH2583-Br-C6H4-CH2M.p.103-105℃594-Br-C6H4-CH260 2-(異丙基)-C6H4-CH261 3-(異丙基)-C6H4-CH262 4-(異丙基)-C6H4-CH263 2-(異丙基)-3-Cl-C6H3-CH264 2-(異丙基)-4-Cl-C6H3-CH265 2-(異丙基)-5-Cl-C6H3-CH266 2-CH3-3-(異丙基)-C6H3-CH267 2-CH3-4-(異丙基)-C6H3-CH268 2-CH3-5-(異丙基)-C6H3-CH2692-t-C4H9-C6H4-CH2703-t-C4H9-C6H4-CH2714-t-C4H9-C6H4-CH2NMR1.91(s，9H)，2.9(d，3H)，3.90(s，3H)，5.15(s，2H)，6.7(s，1H)and 7.18-8.0(m，9H)722-CH3-3-t-C4H9-C6H3-CH2732-CH3-4-t-C4H9-C6H3-CH2742-CH3-5-t-C4H9-C6H3-CH2753-CH3-4-t-C4H9-C6H3-CH2763-CH3-5-t-C4H9-C6H3-CH2772-Cl-3-t-C4H9-C6H3-CH2782-Cl-4-t-C4H9-C6H3-CH2792-Cl-5-t-C4H9-C6H3-CH2803-Cl-4-t-C4H9-C6H3-H2813-Cl-5-t-C4H9-C6H3-CH2822-OCH3-C6H4-CH2833-OCH3-C6H4-CH2NMR2.8(d，3H)，3.80(s，3H)，3.9(s，3H)，5.75(s，2H)，6.7(s，1H)，6.8-8.0(m，9H)844-OCH3-C6H4-CH2852-CH3-3-OCH3-C6H3-CH2862-CH3-5-OCH3-C6H3-CH2873-CH3-4-OCH3-C6H3-CH2883-CH3-5-OCH3-C6H3-CH2892-Cl-3-OCH3-C6H3-CH2902-Cl-4-OCH3-C6H3-CH2912-Cl-5-OCH3-C6H3-CH2922-OCH3-3-Cl-C6H3-CH2932-OCH3-4-Cl-C6H3-CH2942-OCH3-5-Cl-C6H3-CH295 2-CH3-4-(環(huán)己基)-C6H3-CH2962-CH3-4-(C6H5-C6H3-CH2972-CH3-3-Br-C6H3-CH2982-CH3-4-Br-C6H3-CH2992-CH3-5-Br-C6H3-CH21002-CH3-3-(甲氧亞氨基甲基)-C6H3-CH21012-甲氧亞氨基甲基-C6H4-CH41023-甲氧亞氨基甲基-C6H4-CH41032-CH3-4-(甲氧亞氨基甲基)-C6H3-CH21042-苯基-C6H4-CH21053-苯基-C6H4-CH21064-苯基-C6H4-CH21072-苯氧基-C6H4-CH2108 3-苯氧基l-C6H4-CH2l09 4-苯氧基l-C6H4-CH2110 2-芐氧基ty-C6H4-CH2111 3-芐氧基ty-C6H4-CH2112 4-芐氧基ty-C6H4-CH2113 1-萘基yl-CH2114 2-萘基hyl-CH2IR1669，1526，1035，979，819，754115 9-蒽基-CH21162-CH3-3-C6H5O-C6H3-CH21172-CH3-4-C6H5O-C6H3-CH21182-CH3-5-C6H5O-C6H3-CH21193-CH3-4-C6H5O-C6H3-CH21204-CH3-5-C6H5O-C6H3-CH21212-Cl-3-C6H5O-C6H3-CH21222-Cl-4-C6H5O-C6H3-CH21232-Cl-5-C6H5O-C6H3-CH21243-Cl-4-C6H5O-C6H3-CH21253-Cl-5-C6H5OC6H3-CH21262-CH3-4-CO2CH3-C6H3-CH21272-CH3-4-CO2CH3-C6H3-CH2128C6H5-CH(CH3) M.p.105℃1292-F-C6H4-CH(CH3)1302-F-C6H4-CH(CH3)1314-F-C6H4-CH(CH3)1322-Cl-C6H4-CH(CH3)1333-Cl-C6H4-CH(CH3)1344-Cl-C6H4-CH(CH3) NMR1.58(d，3H)，2.9(d，3H)，3.8(s，3H)，5.22(q，1H)，6.69(s，1H)and 7.18-8.0(m，9H)135 2，3-Cl2-C6H3-CH(CH3)136 2，4-Cl2-C6H3-CH(CH3)137 2，5-Cl2-C6H3-CH(CH3)138 2，6-Cl2-C6H3-CH(CH3)139 3，4-Cl2-C6H3-CH(CH3)1402-CH3-C6H4-CH(CH3)1413-CH3-C6H4-CH(CH3)1424-CH3-C6H4-CH(CH3)143 2，3-(CH3)2-C6H3-CH(CH3)144 2，4-(CH3)2-C6H3-CH(CH3)145 2，5-(CH3)2-C6H3-CH(CH3) M.p.114℃146 3，4-(CH3)2-C6H3-CH(CH3)147 3，5-(CH3)2-C6H3-CH(CH3)148 4，5-(CH3)2-C6H3-CH(CH3)150 2，3，4-(CH3)3-C6H2-CH(CH3)151 2，4，5-(CH3)3-C6H2-CH(CH3)152 2，4，6-(CH3)3-C6H2-CH(CH3)153 2，2，6-(CH3)3-C6H2-CH(CH3)1542-CF3-C6H4-CH(CH3)1553-CF3-C6H4-CH(CH3) NMR1.6(d，3H)，2.9(d，3H)，3.85(s，3H)，5.3(q，1H)，6.8(s，1H)and 7.1-8.0(m，9H)1564-CF3-C6H4-CH(CH3)1572-CH3-3-CF3-C6H3-CH(CH3)1582-CH3-4-CF3-C6H3-CH(CH3)1592-CH3-3-CH3-C6H3-CH(CH3)1602-CH3-4-CH3-C6H3-CH(CH3)1612-CH3-5-CH3-C6H3-CH(CH3)1622-CH3-5-CF3-C6H3-CH(CH3)1632-Br-C6H4-CH(CH3)1643-Br-C6H4-CH(CH3)1654-Br-C6H4-CH(CH3)166 2-(異丙基)-C6H4-CH(CH3)167 3-(異丙基)-C6H4-CH(CH3)168 4-(異丙基)-C6H4-CH(CH3)169 2-(異丙基)-3-Cl-C6H3-CH(CH3)170 2-(異丙基)-4-Cl-C6H3-CH(CH3)171 2-(異丙基)-5-Cl-C6H3-CH(CH3)172 2-CH3-3-(異丙基)-C6H3-CH(CH3)173 2-CH3-4-(異丙基)-C6H3-CH(CH3)174 2-CH3-5-(異丙基)-C6H3-CH(CH3)1752-t-C4H9-C6H4-CH-(CH3)1763-t-C4H9-C6H4-CH-(CH3)1774-t-C4H9-C6H4-CH-(CH3)1782-CH3-3-t-C4H9-C6H3-CH(CH3)1792-CH3-4-t-C4H9-C6H3-CH(CH3)1802-CH3-5-t-C4H9-C6H3-CH(CH3)1813-CH3-4-t-C4H9-C6H3-CH(CH3)1823-CH3-5-t-C4H9-C6H3-CH(CH3)1832-Cl-3-t-C4H9-C6H3-CH(CH3)1842-Cl-4-t-C4H9-C6H3-CH(CH3)1853-Cl-4-t-C4H9-C6H3-CH(CH3)1873-Cl-5-t-C4H9-C6H3-CH(CH3)1882-OCH3-C6H4-CH2-CH(CH3)1893-OCH3-C6H4-CH2-CH(CH3)1904-OCH3-C6H4-CH2-CH(CH3)1912-CH3-3-OCH3-C6H3-CH(CH3)1922-CH3-4-OCH3-C6H3-CH(CH3)1932-CH3-5-OCH3-C6H3-CH(CH3)1943-CH3-5-OCH3-C6H3-CH(CH3)1953-CH3-5-OCH3-C6H3-CH(CH3)1962-Cl-3-OCH3-C6H3-CH(CH3)1972-Cl-4-OCH3-C6H3-CH(CH3)1982-Cl-5-OCH3-C6H3-CH(CH3)1992-OCH3-3-Cl-C6H3-CH(CH3)2002-OCH3-4-Cl-C6H3-CH(CH3)2012-OCH3-5-Cl-C6H3-CH(CH3)202 2-CH3-4-(環(huán)己基)-C6H3-CH(CH3)2032-CH3-4-C6H5-C6H3-CH(CH3)2042-CH3-3-Br-C6H3-CH(CH3)2052-CH3-4-Br-C6H3-CH(CH3)2063-CH3-5-Br-C6H3-CH(CH3)207 2-CH3-3-(甲氧亞氨基甲基)-C6H3-CH(CH3)208 2-甲氧亞氨基甲基-C6H4-CH(CH3)209 3-甲氧亞氨基甲基-C6H4-CH(CH3)210 2-CH3-4-(甲氧亞氨基甲基)-C6H3-CH(CH3)211 2-苯基-C6H4-CH(CH3)212 3-苯基1-C6H4-CH(CH3)213 4-苯基1-C6H4-CH(CH3)214 2-苯氧基-C6H4-CH(CH3)215 3-苯氧基-C6H4-CH(CH3)216 4-苯氧基-C6H4-CH(CH3)217 2-芐氧基-C6H4-CH(CH3)218 3-芐氧基-C6H4-CH(CH3)219 4-芐氧基-C6H4-CH(CH3)220 1-萘基-CH(CH3)221 2-萘基-CH(CH3)222 9-蒽基-CH(CH3)2232-CH3-3-C6H5O-C6H3-CH(CH3)2242-CH3-4-C6H5O-C6H3-CH(CH3)2252-CH3-5-C6H5O-C6H3-CH(CH3)2263-CH3-4-C6H5O-C6H3-CH(CH3)2274-CH3-5-C6H5O-C6H3-CH(CH3)2282-Cl-3-C6H5O-C6H3-CH(CH3)2292-Cl-4-C6H5O-C6H3-CH(CH3)2302-Cl-5-C6H5O-C6H3-CH(CH3)2313-Cl-4-C6H5O-C6H3-CH(CH3)2323-Cl-5-C6H5O-C6H3-CH(CH3)2332-CH3-4-CO2CH3-C6H3-CH(CH3)2342-CH3-5-CO2CH3-C6H3-CH(CH3)235C6H5-(CH2)22362-F-C6H4-(CH2)22373-F-C6H4-(CH2)22384-F-C6H4-(CH2)22392-Cl-C6H4-(CH2)22403-Cl-C6H4-(CH2)22414-Cl-C6H4-(CH2)2242 2，3-Cl2-C6H3-(CH2)2243 2，4-Cl2-C6H3-(CH2)2244 2，5-Cl2-C6H3-(CH2)2245 2，6-Cl2-C6H3-(CH2)2246 3，4-Cl2-C6H3-(CH2)22472-CH3-C6H4-(CH2)22483-CH3-C6H4-(CH2)22494-CH3-C6H4-(CH2)2250 2，3-(CH3)2-C6H3-(CH2)2251 2，3-(CH3)2-C6H3-(CH2)2252 2，5-(CH3)2-C6H3-(CH2)2253 3，4-(CH3)2-C6H3-(CH2)2254 3，5-(CH3)2-C6H3-(CH2)2255 4，5-(CH3)2-C6H3-(CH2)2256 2，3，4-(CH3)3-C6H2-(CH2)2257 2，4，5-(CH3)3-C6H2-(CH2)2258 2，4，6-(CH3)3-C6H2-(CH2)2259 2，2，6-(CH3)3-C6H2-(CH2)22602-CF3-C6H4-(CH2)22612-CF3-C6H4-(CH2)22624-CF3-C6H4-(CH2)22632-CH3-3-CF3-C6H3-(CH2)22642-CH3-4-CF3-C6H3-(CH2)22652-CF3-3-CH3-C6H3-(CH2)22662-CF3-4-CH3-C6H3-(CH2)22672-CF3-5-CH3-C6H3-(CH2)22682-CH3-3-CH3-C6H3-(CH2)22692-Br-C6H4-(CH2)22703-Br-C6H4-(CH2)22714-Br-C6H4-(CH2)2272 2-(異丙基)-C6H4-(CH2)2273 3-(異丙基)-C6H4-(CH2)2274 4-(異丙基)-C6H4-(CH2)2275 2-(異丙基)-3-Cl-C6H3-(CH2)2276 2-(異丙基)-4-Cl-C6H3-(CH2)2277 2-(異丙基)-5-Cl-C6H3-(CH2)2278 2-CH3-3-(異丙基)-C6H3-(CH2)2279 2-CH3-4-(異丙基)-C6H3-(CH2)2280 2-CH3-5-(異丙基)-C6H3-(CH2)22812-t-C4H9-C6H4-(CH2)22823-t-C4H9-C6H4-(CH2)22834-t-C4H9-C6H4-(CH2)22842-CH3-3-t-C4H9-C6H3-(CH2)22852-CH3-4-t-C4H9-C6H3-(CH2)22862-CH3-5-t-C4H9-C6H3-(CH2)22873-CH3-4-t-C4H9-C6H3-(CH2)22883-CH3-5-t-C4H9-C6H3-(CH2)22892-Cl-3-t-C4H9-C6H3-(CH2)22902-Cl-4-t-C4H9-C6H3-(CH2)22912-Cl-5-t-C4H9-C6H3-(CH2)22923-Cl-4-t-C4H9-C6H3-(CH2)22933-Cl-5-t-C4H9-C6H3-(CH2)22942-OCH3-C6H4-(CH2)22953-OCH3-C6H4-(CH2)22964-OCH3-C6H4-(CH2)22972-CH3-3-OCH3-C6H3-(CH2)22982-CH3-4-OCH3-C6H3-(CH2)22992-CH3-5-OCH3-C6H3-(CH2)23003-CH3-4-OCH3-C6H3-(CH2)23013-CH3-5-OCH3-C6H3-(CH2)23022-Cl-3-OCH3-C6H3-(CH3)23032-Cl-4-OCH3-C6H3-(CH3)23042-Cl-5-OCH3-C6H3-(CH3)23052-OCH3-3-Cl-C6H3-(CH3)23062-OCH3-4-Cl-C6H3-(CH3)23072-OCH3-5-Cl-C6H3-(CH3)2308 2-CH3-4-(環(huán)己基)-C6H3-(CH2)23092-CH3-4-C6H5-C6H3-(CH2)23102-CH3-3-Br-C6H3-(CH2)23112-CH3-4-Br-C6H3-(CH2)23122-CH3-5-Br-C6H3-(CH2)2313 2-CH3-3-(甲氧亞氨基甲基)-C6H3-(CH2)2314 2-甲氧亞氨基甲基-C6H4-(CH2)2315 3-甲氧亞氨基甲基-C6H4-(CH2)2316 2-CH3-4-(甲氧亞氨基甲基)-C6H3-(CH2)2317 2-苯基-C6H4-(CH2)2318 3-苯基-C6H4-(CH2)2319 4-苯基-C6H4-(CH2)2320 2-苯氧基-C6H4-(CH2)2321 3-苯氧基-C6H4-(CH2)2322 4-苯氧基-C6H4-(CH2)2323 2-芐氧基-C6H4-(CH2)2324 2-芐氧基-C6H4-(CH2)2325 4-芐氧基-C6H4-(CH2)2326 1-萘基-(CH2)2327 2-萘基-(CH2)2328 9-蒽基-(CH2)23292-CH3-3-C6H5O-C6H3-(CH2)23302-CH3-4-C6H5O-C6H3-(CH2)23312-CH3-5-C6H5O-C6H3-(CH2)23323-CH3-4-C6H5O-C6H3-(CH2)23334-CH3-5-C6H5O-C6H3-(CH2)23342-Cl-3-C6H5O-C6H3-(CH2)23352-Cl-4-C6H5O-C6H3-(CH2)23362-Cl-5-C6H5O-C6H3-(CH2)23373-Cl-4-C6H5O-C6H3-(CH2)23383-Cl-5-C6H5O-C6H3-(CH2)23392-CH3-4-CO2CH3-C6H3-(CH2)23402-CH3-5-CO2CH3-C6H3-(CH2)2341C6H5-CH＝CH-CH23422-F-C6H4-CH＝CH-CH23432-F-C6H4-CH＝CH-CH23444-F-C6H4-CH＝CH-CH23452-Cl-C6H4-CH＝CH-CH23463-Cl-C6H4-CH＝CH-CH23474-Cl-C6H4-CH＝CH-CH2348 2，3-Cl2-C6H3-CH＝CH-CH2349 2，4-Cl2-C6H3-CH＝CH-CH2350 2，5-Cl2-C6H3-CH＝CH-CH2351 2，6-Cl2-C6H3-CH＝CH-CH2352 3，4-Cl2-C6H3-CH＝CH-CH23532-CH3-C6H4-CH＝CH-CH23543-CH3-C6H4-CH＝CH-CH23554-CH3-C6H4-CH＝CH-CH2356 2，3-(CH3)2-C6H3-CH＝CH-CH2357 2，4-(CH3)2-C6H3-CH＝CH-CH2358 2，5-(CH3)2-C6H3-CH＝CH-CH2359 3，4-(CH3)2-C6H3-CH＝CH-CH2360 3，5-(CH3)2-C6H3-CH＝CH-CH2361 4，5-(CH3)2-C6H3-CH＝CH-CH2362 2，3，4-(CH3)3-C6H2-CH＝CH-CH2363 2，4，5-(CH3)3-C6H2-CH＝CH-CH2364 2，4，6-(CH3)3-C6H2-CH＝CH-CH2365 2，3，6-(CH3)3-C6H2-CH＝CH-CH23662-CF3-C6H4-CH＝CH-CH23673-CF3-C6H4-CH＝CH-CH23684-CF3-C6H4-CH＝CH-CH23692-CH3-3-CF3-C6H3-CH＝CH-CH23702-CH3-4-CF3-C6H3-CH＝CH-CH23712-CF3-3-CF3-C6H3-CH＝CH-CH23722-CF3-4-CF3-C6H3-CH＝CH-CH23732-CF3-5-CF3-C6H3-CH＝CH-CH23742-CH3-5-CF3-C6H3-CH＝CH-CH2375C6H5-(CH2)3376C6H5-(CH2)4377C6H5-CH2CH＝CH-CH23784-F-C6H4-CH＝CH-(CH2)2379CH3O-CO-CH2380CH3CH2O-CO-CO2381CH3-CO-CH2-CH2382t-C4H9O-CO-CH2383t-C4H9O-CO-(CH2)2384t-C4H9O-CO-CH(CH3) NMR1.42(d，9H)，1.5(s，9H)，2.96(d，3H)，3.97(s，3H)，4.62(q，9H)，6.87(s，1H)，7.18-8.0(m，9H)385n-C4H9O-CO-CH2386 異-C4H9O-CO-CH2387n-C3H7O-CO-CH2388 仲-C4H9O-COCH2389C6H5-CO-CH23902-CH3-C6H4C-CO-CH23913-CH3-C6H4C-CO-CH23924-CH3-C6H4C-CO-CH23932-Cl-C6H4O-CO-CH23943-Cl-C6H4O-CO-CH23954-Cl-C6H4-CO-CH2396C6H5-C(CH3)＝CH-CH2IR1662，1527，1445，1035，987，757397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452M.p.95-97℃453 454 455 456 457 458 459 460 461 462N≡C-CH2463t-BuO-CH2-CH＝CH-CH2464(CH3)2-C＝CH-CH2-CH2-C(CH3)＝CH-CH2465(CH3)2CH-C＝CH-CH2-CH2-C(CH3)＝CH-CH2466C6H5-O-CH(CH3)-CH24674-Cl-C6H4-C-CH(CH3)-CH2NMR1.3(d，3H)，2.9(d，3H)，3.9(s，3H)，4.1-4.35(m，2H)，4.65(m，1H)，6.8-7.9(m，10H)
表2 化合物編號(hào) R21 H2 CH33 CH3CH24 CH3CH2CH25 CH2＝CH-CH26 CH2＝C(Cl)-CH27 CH3-CH＝CH-CH(CH3)8 CH2＝C(CH3)-CH29 HC＝C-CH210 CH3-O-CH2-CH211 C2H5-O-CH2-CH212 Cl-CH2-CH213 Cyclo-C3H5-CH214 CH3-CH＝CH-CH215 CH2＝CH-CH2-CH216 CH3-C≡C-CH217 CH3CH2-C≡C-CH218 CH3-(CH2)319 CH3-(CH2)420 (CH3)3C21 環(huán)-C6H1122 2-CH3-環(huán)-C6H1023 C6H5-CH224 2-F-C6H4-CH225 3-F-C6H4-CH226 4-F-C6H4-CH227 2-Cl-C6H4-CH228 3-Cl-C6H4-CH229 4-Cl-C6H4-CH230 2，3-Cl2-C6H3-CH231 2，4-Cl2-C6H3-CH232 3，5-Cl2-C6H3-CH233 2，6-Cl2-C6H3-CH234 3，4-Cl2-C6H3-CH235 2-CH3-C6H4-CH2374-CH3-C6H4-CH238 2，3-(CH3)2-C6H3-CH239 2，4-(CH3)2-C6H3-CH240 2，5-(CH3)2-C6H3-CH241 3，4-(CH3)2-C6H3-CH242 3，5-(CH3)2-C6H3-CH243 4，5-(CH3)2-C6H3-CH244 2，3，4-(CH3)3-C6H2-CH245 2，4，5-(CH3)3-C6H2-CH246 2，4，6-(CH3)3-C6H2-CH247 2，3，6-(CH3)3-C6H2-CH2482-CF3-C6H4-CH2493-CF3-C6H4-CH2504-CF3-C6H4-CH2512-CH3-3-CF3-C6H3-CH2522-CH3-4-CF3-C6H3-CH2532-CF3-3-CH3-C6H3-CH3542-CF3-4-CH3-C6H3-CH2552-CF3-5-CH3-C6H3-CH2562-CH3-5-CF3-C6H3-CH2572-Br-C6H4-CH2583-Br-C6H4-CH2594-Br-C6H4-CH260 2-(異丙基pyl)-C6H4-CH261 3-(異丙基yl)-C6H4-CH262 4-(異丙基yl)-C6H4-CH263 2-(異丙基yl)-3-Cl-C6H3-CH264 2-(異丙基yl)-4-Cl-C6H3-CH265 2-(異丙基yl)-5-Cl-C6H3-CH266 2-CH3-3-(異丙基yl)-C6H3-CH267 2-CH3-4-(異丙基yl)-C6H3-CH268 2-CH3-5-(異丙基yl)-C6H3-CH2692-t-C4H9-C6H4-CH2703-t-C4H9-C6H4-CH2714-t-C4H9-C6H4-CH2722-CH3-3-t-C4H9-C6H3-CH2732-CH3-4-t-C4H9-C6H3-CH2742-CH3-5-t-C4H9-C6H3-CH2753-CH3-4-t-C4H9-C6H3-CH2763-CH3-5-t-C4H9-C6H3-CH2772-Cl-3-t-C4H9-C6H3-CH2782-Cl-4-t-C4H9-C6H3-CH2792-Cl-5-t-C4H9-C6H3-CH2803-Cl-4-t-C4H9-C6H3-H2813-Cl-5-t-C4H9-C6H3-CH2822-OCH3-C6H4-CH2833-OCH3-C6H4-CH2844-OCH3-C6H4-CH2852-CH3-3-OCH3-C6H3-CH2862-CH3-5-OCH3-C6H3-CH2873-CH3-4-OCH3-C6H3-CH2883-CH3-5-OCH3-C6H3-CH2892-Cl-3-OCH3-C6H3-CH2902-Cl-4-OCH3-C6H3-CH2912-Cl-5-OCH3-C6H3-CH2922-OCH3-3-Cl-C6H3-CH2932-OCH3-4-Cl-C6H3-CH2942-OCH3-5-Cl-C6H3-CH295 2-CH3-4-(環(huán)己基)-C6H3-CH2962-CH3-4-(C6H5-C6H3-CH2972-CH3-3-Br-C6H3-CH2982-CH3-4-Br-C6H3-CH2992-CH3-5-Br-C6H3-CH21002-CH3-3-(甲氧亞氨基甲基)-C6H3-CH21012-(甲氧亞氨基甲基)-C6H4-CH41023-(甲氧亞氨基甲基)-C6H4-CH41032-CH3-4-(甲氧亞氨基甲基)-C6H3-CH21042-苯基-C6H4-CH21053-苯基-C6H4-CH21064-苯基-C6H4-CH21072-苯氧基-C6H4-CH21083-苯氧基-C6H4-CH21094-苯氧基-C6H4-CH21102-芐氧基-C6H4-CH21113-芐氧基-C6H4-CH21124-芐氧基-C6H4-CH21131-萘基-CH21142-萘基-CH21159-蒽基-CH2116 2-CH3-3-C6H5O-C6H3-CH2117 2-CH3-4-C6H5O-C6H3-CH2118 2-CH3-5-C6H5O-C6H3-CH2119 3-CH3-4-C6H5O-C6H3-CH2120 4-CH3-5-C6H5O-C6H3-CH2121 2-Cl-3-C6H5O-C6H3-CH2122 2-C1-4-C6H5O-C6H3-CH2123 2-Cl-5-C6H5O-C6H3-CH2124 3-Cl-4-C6H5O-C6H3-CH2125 3-Cl-5-C6H5OC6H3-CH2126 2-CH3-4-CO2CH3-C6H3-CH2127 2-CH3-4-CO2CH3-C6H3-CH2128 C6H5-CH(CH3)129 2-F-C6H4-CH(CH3)130 2-F-C6H4-CH(CH3)1314-F-C6H4-CH(CH3)1322-Cl-C6H4-CH(CH3)1333-Cl-C6H4-CH(CH3)1344-Cl-C6H4-CH(CH3)135 2，3-Cl2-C6H3-CH(CH3)136 2，4-Cl2-C6H3-CH(CH3)137 2，5-Cl2-C6H3-CH(CH3)138 2，6-Cl2-C6H3-CH(CH3)139 3，4-Cl2-C6H3-CH(CH3)1402-CH3-C6H4-CH(CH3)1413-CH3-C6H4-CH(CH3)1424-CH3-C6H4-CH(CH3)143 2，3-(CH3)2-C6H3-CH(CH3)144 2，4-(CH3)2-C6H3-CH(CH3)145 2，5-(CH3)2-C6H3-CH(CH3)146 3，4-(CH3)2-C6H3-CH(CH3)147 3，5-(CH3)2-C6H3-CH(CH3)148 4，5-(CH3)2-C6H3-CH(CH3)150 2，3，4-(CH3)3-C6H2-CH(CH3)151 2，4，5-(CH3)3-C6H2-CH(CH3)152 2，4，6-(CH3)3-C6H2-CH(CH3)153 2，2，6-(CH3)3-C6H2-CH(CH3)1542-CF3-C6H4-CH(CH3)1553-CF3-C6H4-CH(CH3)1564-CF3-C6H4-CH(CH3)1572-CH3-3-CF3-C6H3-CH(CH3)1582-CH3-4-CF3-C6H3-CH(CH3)1592-CH3-3-CH3-C6H3-CH(CH3)1602-CH3-4-CH3-C6H3-CH(CH3)1612-CH3-5-CH3-C6H3-CH(CH3)1622-CH3-5-CF3-C6H3-CH(CH3)1632-Br-C5H4-CH(CH3)1643-Br-C6H4-CH(CH3)1654-Br-C6H4-CH(CH3)166 2-(異丙基)-C6H4-CH(CH3)167 3-(異丙基)-C6H4-CH(CH3)168 4-(異丙基)-C6H4-CH(CH3)169 2-(異丙基)-3-Cl-C6H3-CH(CH3)170 2-(異丙基)-4-Cl-C6H3-CH(CH3)171 2-(異丙基)-5-Cl-C6H3-CH(CH3)172 2-CH3-3-(異丙基)-C6H3-CH(CH3)173 2-CH3-4-(異丙基)-C6H3-CH(CH3)174 2-CH3-5-(異丙基)-C6H3-CH(CH3)1752-t-C4H9-C6H4-CH-(CH3)1763-t-C4H9-C6H4-CH-(CH3)1774-t-C4H9-C6H4-CH-(CH3)1782-CH3-3-t-C4H9-C6H3-CH(CH3)1792-CH3-4-t-C4H9-C6H3-CH(CH3)1802-CH3-5-t-C4H9-C6H3-CH(CH3)1813-CH3-4-t-C4H9-C6H3-CH(CH3)1823-CH3-5-t-C4H9-C6H3-CH(CH3)1832-Cl-3-t-C4H9-C6H3-CH(CH3)1842-Cl-4-t-C4H9-C6H3-CH(CH3)1853-Cl-4-t-C4H9-C6H3-CH(CH3)1873-Cl-5-t-C4H9-C6H3-CH(CH3)1882-OCH3-C6H4-CH2-CH(CH3)1893-OCH3-C6H4-CH2-CH(CH3)1904-OCH3-C6H4-CH2-CH(CH3)1912-CH3-3-OCH3-C6H3-CH(CH3)1922-CH3-4-OCH3-C6H3-CH(CH3)1932-CH3-5-OCH3-C6H3-CH(CH3)1943-CH3-5-OCH3-C6H3-CH(CH3)1953-CH3-5-OCH3-C6H3-CH(CH3)1962-Cl-3-OCH3-C6H3-CH(CH3)1972-Cl-4-OCH3-C6H3-CH(CH3)1982-Cl-5-OCH3-C6H3-CH(CH3)1992-OCH3-3-Cl-C6H3-CH(CH3)2002-OCH3-4-Cl-C6H3-CH(CH3)2012-OCH3-5-Cl-C6H3-CH(CH3)202 2-CH3-4-(環(huán)己基)-C6H3-CH(CH3)2032-CH3-4-C6H5-C6H3-CH(CH3)2042-CH3-3-Br-C6H3-CH(CH3)2052-CH3-4-Br-C6H3-CH(CH3)2063-CH3-5-Br-C6H3-CH(CH3)207 2-CH3-3-(甲氧亞氨基甲基)-C6H3-CH(CH3)208 2-甲氧亞氨基甲基-C6H4-CH(CH3)209 3-甲氧亞氨基甲基-C6H4-CH(CH3)210 2-CH3-4-(甲氧亞氨基甲基)-C6H3-CH(CH3)211 2-苯基-C6H4-CH(CH3)212 3-苯基-C6H4-CH(CH3)213 4-苯基-C6H4-CH(CH3)214 2-苯氧基-C6H4-CH(CH3)215 3-苯氧基-C6H4-CH(CH3)216 4-苯氧基-C6H4-CH(CH3)217 2-芐氧基-C6H4-CH(CH3)218 3-芐氧基-C6H4-CH(CH3)219 4-芐氧基-C6H4-CH(CH3)220 1-萘基-CH(CH3)221 2-萘基-CH(CH3)222 9-蒽基-CH(CH3)2232-CH3-3-C6H5O-C6H3-CH(CH3)2242-CH3-4-C6H5O-C6H3-CH(CH3)2252-CH3-5-C6H5O-C6H3-CH(CH3)2263-CH3-4-C6H5O-C6H3-CH(CH3)2274-CH3-5-C6H5O-C6H3-CH(CH3)2282-Cl-3-C6H5O-C6H3-CH(CH3)2292-Cl-4-C6H5O-C6H3-CH(CH3)2302-Cl-5-C6H5O-C6H3-CH(CH3)2313-Cl-4-C6H5O-C6H3-CH(CH3)2323-Cl-5-C6H5O-C6H3-CH(CH3)2332-CH3-4-CO2CH3-C6H3-CH(CH3)2342-CH3-5-CO2CH3-C6H3-CH(CH3)235C6H5-(CH2)22362-F-C6H4-(CH2)22373-F-C6H4-(CH2)22384-F-C6H4-(CH2)22392-Cl-C6H4-(CH2)22403-Cl-C6H4-(CH2)22414-Cl-C6H4-(CH2)2242 2，3-Cl2-C6H3-(CH2)2243 2，4-Cl2-C6H3-(CH2)2244 2，5-Cl2-C6H3-(CH2)2245 2，6-Cl2-C6H3-(CH2)2246 3，4-Cl2-C6H3-(CH2)22472-CH3-C6H4-(CH2)22483-CH3-C6H4-(CH2)22494-CH3-C6H4-(CH2)2250 2，3-(CH3)2-C6H3-(CH2)2251 2，3-(CH3)2-C6H3-(CH2)2252 2，5-(CH3)2-C6H3-(CH2)2253 3，4-(CH3)2-C6H3-(CH2)2254 3，5-(CH3)2-C6H3-(CH2)2255 4，5-(CH3)2-C6H3-(CH2)2256 2，3，4-(CH3)3-C6H2-(CH2)2257 2，4，5-(CH3)3-C6H2-(CH2)2258 2，4，6-(CH3)3-C6H2-(CH2)2259 2，2，6-(CH3)3-C6H2-(CH2)22602-CF3-C6H4-(CH2)22612-CF3-C6H4-(CH2)22624-CF3-C6H4-(CH2)22632-CH3-3-CF3-C6H3-(CH2)22642-CH3-4-CF3-C6H3-(CH2)22652-CF3-3-CH3-C6H3-(CH2)22662-CF3-4-CH3-C6H3-(CH2)22672-CF3-5-CH3-C6H3-(CH2)22682-CH3-3-CH3-C6H3-(CH2)22692-Br-C6H4-(CH2)22703-Br-C6H4-(CH2)22714-Br-C6H4-(CH2)2272 2-(異丙基)-C6H4-(CH2)2273 3-(異丙基)-C6H4-(CH2)2274 4-(異丙基)-C6H4-(CH2)2275 2-(異丙基)-3-Cl-C6H3-(CH2)2276 2-(異丙基)-4-Cl-C6H3-(CH2)2277 2-(異丙基)-5-Cl-C6H3-(CH2)2278 2-CH3-3-(異丙基)-C6H3-(CH2)2279 2-CH3-4-(異丙基)-C6H3-(CH2)2280 2-CH3-5-(異丙基)-C6H3-(CH2)22812-t-C4H9-C6H4-(CH2)22823-t-C4H9-C6H4-(CH2)22834-t-C4H9-C6H4-(CH2)22842-CH3-3-t-C4H9-C6H3-(CH2)22852-CH3-4-t-C4H9-C6H3-(CH2)22862-CH3-5-t-C4H9-C6H3-(CH2)22873-CH3-4-t-C4H9-C6H3-(CH2)22883-CH3-5-t-C4H9-C6H3-(CH2)22892-Cl-3-t-C4H9-C6H3-(CH2)22902-Cl-4-t-C4H9-C6H3-(CH2)22912-Cl-5-t-C4H9-C6H3-(CH2)22923-Cl-4-t-C4H9-C6H3-(CH2)22933-Cl-5-t-C4H9-C6H3-(CH2)22942-OCH3-C6H4-(CH2)22953-OCH3-C6H4-(CH2)22964-OCH3-C6H4-(CH2)22972-CH3-3-OCH3-C6H3-(CH2)22982-CH3-4-OCH3-C6H3-(CH2)22992-CH3-5-OCH3-C6H3-(CH2)23003-CH3-4-OCH3-C6H3-(CH2)23013-CH3-5-OCH3-C6H3-(CH2)23022-Cl-3-OCH3-C6H3-(CH3)23032-Cl-4-OCH3-C6H3-(CH3)23042-Cl-5-OCH3-C6H3-(CH3)23052-OCH3-3-Cl-C6H3-(CH3)23062-OCH3-4-Cl-C6H3-(CH3)23072-OCH3-5-Cl-C6H3-(CH3)2308 2-CH3-4-(環(huán)己基)-C6H3-(CH2)23092-CH3-4-C6H5-C6H3-(CH2)23102-CH3-3-Br-C6H3-(CH2)23112-CH3-4-Br-C6H3-(CH2)23122-CH3-5-Br-C6H3-(CH2)2313 2-CH3-3-(甲氧亞氨基甲基)-C6H3-(CH2)2314 2-(甲氧亞氨基甲基)-C6H4-(CH2)2315 3-(甲氧亞氨基甲基)-C6H4-(CH2)2316 2-CH3-4-(甲氧亞氨基甲基)-C6H3-(CH2)2317 2-苯基-C6H4-(CH2)2318 3-苯基-C6H4-(CH2)2319 4-苯基-C6H4-(CH2)2320 2-苯氧基-C6H4-(CH2)2321 3-苯氧基-C6H4-(CH2)2322 4-苯氧基-C6H4-(CH2)2323 2-芐氧基-C6H4-(CH2)2324 2-芐氧基-C6H4-(CH2)2325 4-芐氧基-C6H4-(CH2)2326 1-萘基-(CH2)2327 2-萘基-(CH2)2328 9-蒽基-(CH2)23292-CH3-3-C6H5O-C6H3-(CH2)23302-CH3-4-C6H5O-C6H3-(CH2)23312-CH3-5-C6H5O-C6H3-(CH2)23323-CH3-4-C6H5O-C6H3-(CH2)23334-CH3-5-C6H5O-C6H3-(CH2)23342-Cl-3-C6H5O-C6H3-(CH2)23352-Cl-4-C6H5O-C6H3-(CH2)23362-Cl-5-C6H5O-C6H3-(CH2)23373-Cl-4-C6H5O-C6H3-(CH2)23383-Cl-5-C6H5O-C6H3-(CH2)23392-CH3-4-CO2CH3-C6H3-(CH2)23402-CH3-5-CO2CH3-C6H3-(CH2)2341C6H5-CH＝CH-CH23422-F-C6H4-CH＝CH-CH23432-F-C6H4-CH＝CH-CH23444-F-C6H4-CH＝CH-CH23452-Cl-C6H4-CH＝CH-CH23463-Cl-C6H4-CH＝CH-CH23474-Cl-C6H4-CH＝CH-CH2348 2，3-Cl2-C6H3-CH＝CH-CH2349 2，4-Cl2-C6H3-CH＝CH-CH2350 2，5-Cl2-C6H3-CH＝CH-CH2351 2，6-C12-C6H3-CH＝CH-CH2352 3，4-Cl2-C6H3-CH＝CH-CH23532-CH3-C6H4-CH＝CH-CH23543-CH3-C6H4-CH＝CH-CH23554-CH3-C6H4-CH＝CH-CH2356 2，3-(CH3)2-C6H3-CH＝CH-CH2357 2，4-(CH3)2-C6H3-CH＝CH-CH2358 2，5-(CH3)2-C6H3-CH＝CH-CH2359 3，4-(CH3)2-C6H3-CH＝CH-CH2360 3，5-(CH3)2-C6H3-CH＝CH-CH2361 4，5-(CH3)2-C6H3-CH＝CH-CH2362 2，3，4-(CH3)3-C6H2-CH＝CH-CH2363 2，4，5-(CH3)3-C6H2-CH＝CH-CH2364 2，4，6-(CH3)3-C6H2-CH＝CH-CH2365 2，3，6-(CH3)3-C6H2-CH＝CH-CH23662-CF3-C6H4-CH＝CH-CH23673-CF3-C6H4-CH＝CH-CH23684-CF3-C6H4-CH＝CH-CH23692-CH3-3-CF3-C6H3-CH＝CH-CH23702-CH3-4-CF3-C6H3-CH＝CH-CH23712-CF3-3-CF3-C6H3-CH＝CH-CH23722-CF3-4-CF3-C6H3-CH＝CH-CH23732-CF3-5-CF3-C6H3-CH＝CH-CH23742-CH3-5-CF3-C6H3-CH＝CH-CH2375C6H5-(CH2)3376C6H5-(CH2)4377C6H5-CH2CH＝CH-CH23784-F-C6H4-CH＝CH-(CH2)2379CH3O-CO-CH2380CH3CH2O-CO-CO2381CH3-CO-CH2-CH2382t-C4H9O-Co-CH2383t-C4H9O-CO-(CH2)2384t-C4H9O-CO-CH(CH3)385n-C4H9O-CO-CH2386 異-C4H9O-CO-CH2387n-C3H7O-CO-CH2388 仲-C4H9O-COCH2389C6H5-CO-CH23902-CH3-C6H4O-CO-CH23913-CH3-C6H4O-CO-CH23924-CH3-C6H4O-CO-CH23932-Cl-C6H4O-CO-CH23943-Cl-C6H4O-CO-CH23954-Cl-C6H4-CO-CH2396C6H5-C(CH3)＝CH-CH2397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462N≡C-CH2463t-BuO-CH2-CH＝CH-CH2464(CH3)2-C＝CH-CH2-CH2-C(CH3)＝CH-CH2465(CH3)2CH-C＝CH-CH2-CH2-C(CH3)＝CH-CH2466C6H5-O-CH(CH3)-CH24674-Cl-C6H4-O-CH(CH3)
表3 化合物編號(hào)R1R2R61 HH H2 HCH3H3 Ht-C4H9H4 HCH2＝CH-CH2H5 HCH2＝C(-Cl)-CH2H6 HCH2＝C(CH3)-CH2H7 HCH3CH＝CH-CH2H8 HHC≡CCH2H9 HCH3C≡C-CH2H10H環(huán)-C6H11H11HC6H5-CH2H12H2-F-C6H4-CH2H13H3-F-C6H4-CH2H14H4-F-C6H4-CH2H15H2-Cl-C6H4-CH2H16H3-Cl-C6H4-CH2H17H4-Cl-C6H4-CH2H18H2-Br-C6H4-CH2H19H3-Br-C6H4-CH2H20H4-Br-C6H4-CH2H21H2-CH3-C6H4-CH2H22H3-CH3-C6H4-CH2H23H4-CH3-C6H4-CH2H24H2-CF3-C6H4-CH2H25H3-CF3-C6H4-CH2H26H4-CF3-C6H4-CH2H27H2-i-C3H7-C6H4-CH2H28H3-i-C3H7-C6H4-CH2H29H4-i-C3H7-C6H4-CH2H30H2-t-C4H9-C6H4-CH2H31H3-t-C4H9-C6H4-CH2H32H4-t-C4H9-C6H4-CH2H33H2-CH3O-C6H4-CH2H34H3-CH3O-C6H4-CH2H35H4-CH3O-C6H4-CH2H36H2-氰基-C6H4-CH2H37H3-氰基-C6H4-CH2H38H4-氰基-C6H4-CH2H39H2-硝基-C6H4-CH2H40H3-硝基-C6H4-CH2H41H4-硝基-C6H4-CH2H42H2，4-Cl2-C6H3-CH2H43H3，4-Cl2-C6H3-CH2H44H3，5-Cl2-C6H3-CH2H45H2，6-Cl2-C6H3-CH2H46H2，4-(CH3)2-C6H3-CH2H47H2，5-(CH3)2-C6H3-CH2H48H3，4-(CH3)2-C6H3-CH2H49H3，5-(CH3)2-C6H3-CH2H50H1-萘基-CH2H51H2-萘基-CH2H52HC6H5-CH(CH3) H53H2-Cl-C6H4-CH(CH3) H54H3-Cl-C6H4-CH(CH3) H55H4-Cl-C6H4-CH(CH3) H56H2-CH3-C6H4-CH(CH3)H57H3-CH3-C6H4-CH(CH3)H58H4-CH3-C6H4-CH(CH3)H59H2-CF3-C6H4-CH(CH3)H60H3-CF3C6H4-CH(CH3) H61H4-CF-C6H4-CH(CH3) H62H2-t-C4H9-C6H4-CH(CH3)H63H3-t-C4H9-C6H4-CH(CH3)H64H4-t-C4H9-C6H4-CH(CH3)H65H2-CH3O-C6H4-CH(CH3) H66H3-CH3O-C6H4-CH(CH3) H67H4-CH3O-C6H4-CH(CH3) H68H2-氰基-C6H4-CH(CH3)H69H3-氰基-C6H4-CH(CH3)H70H4-氰基-C6H4-CH(CH3)H71H2，4-Cl2-C6H3-CH(CH3) H72H3，4-Cl2-C6H3-CH(CH3) H73H3，5-Cl2-C6H3-CH(CH3) H74H2，4-(CH3)2-C6H3-CH(CH3) H75H2，5-(CH3)2-C6H3-CH(CH3) H76HCH3OOC-CH2H77HC2H5OOC-CH2H78Hi-C3H7OOC-CH2H79Ht-C4H9OOC-CH2H80Ht-C4H9OOC-CH(CH3) H81HN≡C-CH2H82HC6H5CO-CH2H83 H 吡啶-2-基-甲基 H84 H 吡嗪-2-基-甲基 H85 H 嘧啶-2-基-甲基 H86 H 呋喃-2-基-甲基 H87 H 吡咯-2-基-甲基 H88 H N-甲基-吡咯-2-基-甲基 H89 H 噻吩-2-基-甲基 H90 H 異噁唑-5-基-甲基H91 H 噻唑-2-基-甲基 H92 H 噻唑-5-基-甲基 H93 H 噁唑-2-基-甲基 H94 H 吡唑-3-基-甲基 H95 H 苯并呋喃-2-基-甲基 H96 H 吲哚-2-基-甲基 H97 H 吲哚-3-基-甲基 H98 H 苯并噻唑-2-基-甲基 H99 H 喹啉-2-基-甲基 H100 H 4-Cl-C6H4OCH(CH3)-CH2H101 CH3H H102 CH3CH3H103 CH3t-C4H9H104 CH3CH2＝CH-CH2H105 CH3CH2＝C(-Cl)-CH2H106 CH3C(CH3)-CH2H107 CH3CH3CH＝CH-CH2H108 CH3HC≡CCH2H109 CH3CH3C≡C-CH2H110 CH3環(huán)-C6H11H111 CH3C6H5-CH2H112 CH32-F-C6H4-CH2H113 CH33-F-C6H4-CH2H114 CH34-F-C6H4-CH2H115 CH32-Cl-C6H4-CH2H116 CH33-Cl-C6H4-CH2H117 CH34-Cl-C6H4-CH2H118 CH32-Br-C6H4-CH2H119 CH33-Br-C6H4-CH2H120 CH34-Br-C6H4-CH2H121 CH32-CH3-C6H4-CH2H122 CH33-CH3-C6H4-CH2H123 CH34-CH3-C6H4-CH2H124 CH32-CF3-C6H4-CH2H125 CH33-CF3-C6H4-CH2H126 CH34-CF3-C6H4-CH2H127 CH32-i-C3H7-C6H4-CH2H128 CH33-i-C3H7-C6H4-CH2H129 CH34-i-C3H7-C6H4-CH2H130CH32-t-C4H9-C6H4-CH2H131CH33-t-C4H9-C6H4-CH2H132CH34-t-C4H9-C6H4-CH2H133CH32-CH3O-C6H4-CH2H134CH33-CH3O-C6H4-CH2H135CH34-CH3O-C6H4-CH2H136CH32-氰基-C6H4-CH2H137CH33-氰基-C6H4-CH2H138CH34-氰基-C6H4-CH2H139CH32-硝基-C6H4-CH2H140CH33-硝基-C6H4-CH2H141CH34-硝基-C6H4-CH2H142CH32，4-Cl2-C6H3-CH2H143CH33，4-Cl2-C6H3-CH2H144CH33，5-Cl2-C6H3-CH2H145CH32，6-Cl2-C6H3-CH2H146CH32，4-(CH3)2-C6H3-CH2H147CH32，5-(CH3)2-C6H3-CH2H148CH33，4-(CH3)2-C6H3-CH2H149CH33，5-(CH3)2-C6H3-CH2H150CH31-萘基-CH2H151CH32-萘基-CH2H152CH3C6H5-CH(CH3)H153CH32-Cl-C6H4-CH(CH3) H154CH33-Cl-C6H4-CH(CH3) H155CH34-Cl-C6H4-CH(CH3) H156CH3CH3-C6H4-CH(CH3) H157CH33-CH3-C6H4-CH(CH3) H158CH34-CH3-C6H4-CH(CH3) H159CH32-CF3-C6H4-CH(CH3) H160CH33-CF3-C6H4-CH(CH3) H161CH34-CF3-C6H4-CH(CH3) H162CH32-t-C4H9-C6H4-CH(CH3) H163CH33-t-C4H9-C6H4-CH(CH3) H164CH34-t-C4H9-C6H4-CH(CH3) H165CH32-CH3O-C6H4-CH(CH3)H166CH33-CH3O-C6H4-CH(CH3)H167CH34-CH3O-C6H4-CH(CH3)H168CH32-氰基-C6H4-CH(CH3) H169CH33-氰基-C6H4-CH(CH3) H170CH34-氰基-C6H4-CH(CH3) H171CH32，4-C12-C6H3-CH(CH3) H172CH33，4-Cl2-C6H3-CH(CH3) H173CH33，5-Cl2-C6H3-CH(CH3) H174CH32，4-(CH3)2-C6H3-CH(CH3) H175CH32，5-(CH3)2-C6H3-CH(CH3H176CH3CH3OOC-CH2H177 CH3C2H5OOC-CH2H178 CH3i-C3H7OOC-CH2H179 CH3t-C4H9OOC-CH2H180 CH3t-C4H9OOC-CH(CH3) H181 CH3N≡C-CH2H182 CH3C6H5CO-CH2H183 CH3吡啶-2-基-甲基 H184 CH3吡嗪-2-基-甲基 H185 CH3嘧啶-2-基-甲基 H186 CH3呋喃-2-基-甲基 H187 CH3吡咯-2-基-甲基 H188 CH3N-甲基-吡咯-2-基-甲基 H189 CH3噻吩-2-基-甲基 H190 CH3異噁唑-5-基-甲基H191 CH3噻唑-2-基-甲基 H192 CH3噻唑-5-基-甲基 H193 CH3噁唑-2-基-甲基 H194 CH3吡唑-3-基-甲基 H195 CH3苯并呋喃-2-基-甲基 H196 CH3吲哚-2-基-甲基 H197 CH3吲哚-3-基-甲基 H198 CH3苯并噻唑-2-基-甲基 H199 CH3喹啉-2-基-甲基 H200 CH34-Cl-C6H4OCH(CH3)-CH2H201 H H CH3202 H CH3CH3203 H t-C4H9CH3204 H CH2＝CH-CH2CH3205 H CH2＝C(-Cl)-CH2CH3206 H CH2＝C(CH3)-CH2CH3207 H CH3CH＝CH-CH2CH3208 H HC≡CCH2CH3209 H CH3C≡C-CH2CH3210 H 環(huán)-C6H11CH3211 H C6H5-CH2CH3212 H 2-F-C6H4-CH2CH3213 H 3-F-C6H4-CH2CH3214 H 4-F-C6H4-CH2CH3215 H 2-Cl-C6H4-CH2CH3216 H 3-Cl-C6H4-CH2CH3217 H 4-Cl-C6H4-CH2CH3218 H 2-Br-C6H4-CH2CH3219 H 3-Br-C6H4-CH2CH3220 H 4-Br-C6H4-CH2CH3221 H 2-CH3-C6H4-CH2CH3222 H 3-CH3-C6H4-CH2CH3223 H 4-CH3-C6H4-CH2CH3224H2-CF3-C6H4-CH2CH3225H3-CF3-C6H4-CH2CH3226H4-CF3-C6H4-CH2CH3227H2-i-C3H7-C6H4-CH2CH3228H3-i-C3H7-C6H4-CH2CH3229H4-i-C3H7-C6H4-CH2CH3230H2-t-C4H9-C6H4-CH2CH3231H3-t-C4H9-C6H4-CH2CH3232H4-t-C4H9-C6H4-CH2CH3233H2-CH3O-C6H4-CH2CH3234H3-CH3O-C6H4-CH2CH3235H4-CH3O-C6H4-CH2CH3236H2-氰基-C6H4-CH2CH3237H3-氰基-C6H4-CH2CH3238H4-氰基-C6H4-CH2CH3239H2-硝基-C6H4-CH2CH3240H3-硝基-C6H4-CH2CH3241H4-硝基-C6H4-CH2CH3242H2，4-Cl2-C6H3-CH2CH3243H3，4-Cl2-C6H3-CH2CH3244H3，5-Cl2-C6H3-CH2CH3245H2，6-Cl2-C6H3-CH2CH3246H2，4-(CH3)2-C6H3-CH2CH3247H2，5-(CH3)2-C6H3-CH2CH3248H3，4-(CH3)2-C6H3-CH2CH3249H3，5-(CH3)2-C6H3-CH2CH3250H1-萘基-CH2CH3251H2-萘基-CH2CH3252HC6H5-CH(CH3) CH3253H2-Cl-C6H4-CH(CH3) CH3254H3-Cl-C6H4-CH(CH3) CH3255H4-Cl-C6H4-CH(CH3) CH3256H2-CH3-C6H4-CH(CH3) CH3257H3-CH3-C6H4-CH(CH3) CH3258H4-CH3-C6H4-CH(CH3) CH3259H2-CF3-C6H4-CH(CH3) CH3260H3-CF3-C6H4-CH(CH3) CH3261H4-CF3-C6H4-CH(CH3) CH3262H2-t-C4H9-C6H4-CH(CH3) CH3263H3-t-C4H9-C6H4-CH(CH3) CH3264H4-t-C4H9-C6H4-CH(CH3) CH3265H2-CH3O-C6H4-CH(CH3) CH3266H3-CH3O-C6H4-CH(CH3) CH3267H4-CH3O-C6H4-CH(CH3) CH3268H2-氰基-C6H4-CH(CH3) CH3269H3-氰基-C6H4-CH(CH3) CH3270H4-氰基-C6H4-CH(CH3) CH3271H2，4-Cl2-C6H3-CH(CH3) CH3272H3，4-Cl2-C6H3-CH(CH3) CH3273H3，5-Cl2-C6H3-CH(CH3) CH3274H2，4-(CH3)2-C6H3-CH(CH3) CH3275H2，5-(CH3)2-C6H3-CH(CH3) CH3276HCH3OOC-CH2CH3277HC2H5OOC-CH2CH3278Hi-C3H7OOC-CH2CH3279Ht-C4H9OOC-CH2CH3280Ht-C4H9OOC-CH(CH3)CH3281HN≡C-CH2CH3282HC6H5CO-CH2CH3283H吡啶-2-基-甲基 CH3284H吡嗪-2-基-甲基 CH3285H嘧啶-2-基-甲基 CH3286H呋喃-2-基-甲基 CH3287H吡咯-2-基-甲基 CH3288HN-甲基-吡咯-2-基-甲基CH3289H噻吩-2-基-甲基 CH3290H異噁唑-5-基-甲基 CH3291H噻唑-2-基-甲基 CH3292H噻唑-5-基-甲基 CH3293H噁唑-2-基-甲基 CH3294H吡唑-3-基-甲基 CH3295H苯并呋喃-2-基-甲基 CH3296H吲哚-2-基-甲基 CH3297H吲哚-3-基-甲基 CH3298H苯并噻唑-2-基-甲基 CH3299H喹啉-2-基-甲基 CH3300H4-Cl-C6H4OCH(CH3)-CH2CH3301CH3H CH3302CH3CH3CH3303CH3t-C4H9CH3304CH3CH2＝CH-CH2CH3305CH3CH2＝C(-Cl)-CH2CH3306CH3CH2＝C(CH3)-CH2CH3307CH3CH3CH＝CH-CH2CH3308CH3HC≡CCH2CH3309CH3CH3C≡C-CH2CH3310CH3環(huán)-C6H11CH3311CH3C6H5-CH2CH3332CH32-F-C6H4-CH2CH3313CH33-F-C6H4-CH2CH3314CH34-F-C6H4-CH2CH3315CH32-Cl-C6H4-CH2CH3316CH33-Cl-C6H4-CH2CH3317CH34-Cl-C6H4-CH2CH3318CH32-Br-C6H4-CH2CH3319CH33-Br-C6H4-CH2CH3320CH34-Br-C6H4-CH2CH3321CH32-CH3-C6H4-CH2CH3322CH33-CH3-C6H4-CH2CH3323CH34-CH3-C6H4-CH2CH3324CH32-CF3-C6H4-CH2CH3325CH33-CF3-C6H4-CH2CH3326CH34-CF3-C6H4-CH2CH3327CH32-i-C3H7-C6H4-CH2CH3328CH33-i-C3H7-C6H4-CH2CH3329CH34-i-C3H7-C6H4-CH2CH3330CH32-t-C4H9-C6H4-CH2CH3331CH33-t-C4H9-C6H4-CH2CH3332CH34-t-C4H9-C6H4-CH2CH3333CH32-CH3O-C6H4-CH2CH3334CH33-CH3O-C6H4-CH2CH3335CH34-CH3O-C6H4-CH2CH3336CH32-氰基-C6H4-CH2CH3337CH33-氰基-C6H4-CH2CH3338CH34-氰基-C6H4-CH2CH3339CH32-硝基-C6H4-CH2CH3340CH33-硝基-C6H4-CH2CH3341CH34-硝基-C6H4-CH2CH3342CH32，4-Cl2-C6H3-CH2CH3343CH33，4-Cl2-C6H3-CH2CH3344CH33，5-Cl2-C6H3-CH2CH3345CH32，6-Cl2-C6H3-CH2CH3346CH32，4-(CH3)2-C6H3-CH2CH3347CH32，5-(CH3)2-C6H3-CH2CH3348CH33，4-(CH3)2-C6H3-CH2CH3349CH33，5-(CH3)2-C6H3-CH2CH3350CH31-萘基-CH2CH3351CH32-萘基-CH2CH3352CH3C6H5-CH(CH3)CH3353CH32-Cl-C6H4-CH(CH3) CH3354CH33-Cl-C6H4-CH(CH3) CH3355CH34-Cl-C6H4-CH(CH3) CH3356CH32-CH3-C6H4-CH(CH3) CH3357CH33-CH3-C6H4-CH(CH3) CH3358CH34-CH3-C6H4-CH(CH3) CH3359CH32-CF3-C6H4-CH(CH3) CH3360CH33-CF3-C6H4-CH(CH3) CH3361CH34-CF3-C6H4-CH(CH3) CH3362CH32-t-C4H9-C6H4-CH(CH3) CH3363CH33-t-C4H9-C6H4-CH(CH3) CH3364CH34-t-C4H9-C6H4-CH(CH3) CH3365CH32-CH3O-C6H4-CH(CH3) CH3366CH33-CH3O-C6H4-CH(CH3) CH3367CH34-CH3O-C6H-CH(CH3) CH3368CH32-氰基-C6H4-CH(CH3) CH3369CH33-氰基-C6H4-CH(CH3) CH3370CH34-氰基-C6H4-CH(CH3) CH3371CH32，4-Cl2-C6H3-CH(CH3) CH3372CH33，4-Cl2-C6H3-CH(CH3) CH3373CH33，5-Cl2-C6H3-CH(CH3) CH3374CH32，4-(CH3)2-C6H3-CH(CH3) CH3375CH32，5-(CH3)2-C6H3-CH(CH3CH3376CH3CH3OOC-CH2CH3377CH3C2H5OOC-CH2CH3378CH3i-C3H7OOC-CH2CH3379CH3t-C4H9OOC-CH2CH3380CH3t-C4H9OOC-CH(CH3)CH3381CH3N≡C-CH2CH3382CH3C6H5CO-CH2CH3383CH3吡啶-2-基-甲基 CH3384CH3吡嗪-2-基-甲基 CH3385CH3嘧啶-2-基-甲基 CH3386CH3呋喃-2-基-甲基 CH3387CH3吡咯-2-基-甲基 CH3388CH3N-甲基-吡咯-2-基-甲基CH3389CH3噻吩-2-基-甲基 CH3390CH3異噁唑-5-基-甲基 CH3391CH3噻唑-2-基-甲基 CH3392CH3噻唑-5-基-甲基 CH3393CH3噁唑-2-基-甲基 CH3394CH3吡唑-3-基-甲基 CH3395CH3苯并呋喃-2-基-甲基 CH3396CH3吲哚-2-基-甲基 CH3397CH3吲哚-3-基-甲基 CH3398CH3苯并噻唑-2-基-甲基 CH3399CH3喹啉-2-基-甲基 CH3400CH34-Cl-C6H4OCH(CH3)-CH2CH3
表4 化合物編號(hào)R1R2R41 HH H2 HCH3H3 Ht-C4H9H4 HCH2＝CH-CH2H5 HCH2＝C(-Cl)-CH2H6 HCH2＝C(CH3)-CH2H7 HCH3CH＝CH-CH2H8 HHC≡CCH2H9 HCH3C≡C-CH2H10H環(huán)-C6H11H11HC6H5-CH2H12H2-F-C6H4-CH2H13H3-F-C6H4-CH2H14H4-F-C6H4-CH2H15H2-Cl-C6H4-CH2H16H3-Cl-C6H4-CH2H17H4-Cl-C6H4-CH2H18H2-Br-C6H4-CH2H19H3-Br-C6H4-CH2H20H4-Br-C6H4-CH2H21H2-CH3-C6H4-CH2H22H3-CH3-C6H4-CH2H23H4-CH3-C6H4-CH2H24H2-CF3-C6H4-CH2H25H3-CF3-C6H4-CH2H26H4-CF3-C6H4-CH2H27H2-i-C3H7-C6H4-CH2H28H3-i-C3H7-C6H4-CH2H29H4-i-C3H7-C6H4-CH2H30H2-t-C4H9-C6H4-CH2H31H3-t-C4H9-C6H4-CH2H32H4-t-C4H9-C6H4-CH2H33H2-CH3O-C6H4-CH2H34H3-CH3O-C6H4-CH2H35H4-CH3O-C6H4-CH2H36H2-氰基-C6H4-CH2H37H3-氰基-C6H4-CH2H38H4-氰基-C6H4-CH2H39H2-硝基-C6H4-CH2H40H3-硝基-C6H4-CH2H41H4-硝基-C6H4-CH2H42H2，4-Cl2-C6H3-CH2H43H3，4-Cl2-C6H3-CH2H44H3，5-Cl2-C6H3-CH2H45H2，6-Cl2-C6H3-CH2H46H2，4-(CH3)2-C6H3-CH2H47H2，5-(CH3)2-C6H3-CH2H48H3，4-(CH3)2-C6H3-CH2H49H3，5-(CH3)2-C6H3-CH3H50H1-萘基-CH2H51H2-萘基-CH2H52HC6H5-CH(CH3)H53H2-Cl-C6H4-CH(CH3) H54H3-Cl-C6H4-CH(CH3) H55H4-Cl-C6H4-CH(CH3) H56H2-CH3-C6H4-CH(CH3) H57H3-CH3-C6H4-CH(CH3) H58H4-CH3-C6H4-CH(CH3) H59H2-CF3-C6H4-CH(CH3) H60H3-CF3-C6H4-CH(CH3) H61H4-CF3-C6H4-CH(CH3) H62H2-t-C4H9-C6H4-CH(CH3) H63H3-t-C4H9-C6H4-CH(CH3) H64H4-t-C4H9-C6H4-CH(CH3) H65H2-CH3O-C6H4-CH(CH3)H66H3-CH3O-C6H4-CH(CH3)H67H4-CH3O-C6H4-CH(CH3)H68H2-氰基-C6H4-CH(CH3) H69H3-氰基-C6H4-CH(CH3) H70H4-氰基-C6H4-CH(CH3) H71H2，4-Cl2-C6H3-CH(CH3) H72H3，4-Cl2-C6H3-CH(CH3) H73H3，5-Cl2-C6H3-CH(CH3) H74H2，4-(CH3)2-C6H3-CH(CH3) H75H2，5-(CH3)2-C6H3-CH(CH3) H76HCH3OOC-CH2H77HC2H5OOC-CH2H78Hi-C3H7OOC-CH2H79Ht-C4H9OOC-CH2H80Ht-C4H9OOC-CH(CH3)H81 HN≡C-CH2H82 HC6H5CO-CH2H83 H吡啶-2-基-甲基H84 H吡嗪-2-基-甲基H85 H嘧啶-2-基-甲基H86 H呋喃-2-基-甲基H87 H吡咯-2-基-甲基H88 HN-甲基-吡咯-2-基-甲基 H89 H噻吩-2-基-甲基H90 H異噁唑-5-基-甲基 H91 H噻唑-2-基-甲基H92 H噻唑-5-基-甲基H93 H噁唑-2-基-甲基H94 H吡唑-3-基-甲基H95 H苯并呋喃-2-基-甲基H96 H吲哚-2-基-甲基H97 H吲哚-3-基-甲基H98 H苯并噻唑-2-基-甲基H99 H喹啉-2-基-甲基H100 H4-Cl-C6H4OCH(CH3)-CH2H101 CH3H H102 CH3CH3H103 CH3t-C4H9H104 CH3CH2＝CH-CH2H105 CH3CH2＝C(-Cl)-CH2H106 CH3C(CH3)-CH2H107 CH3CH3CH＝CH-CH2H108 CH3HC≡CCH2H109 CH3CH3C≡C-CH2H110 CH3環(huán)-C6H11H111 CH3C6H5-CH2H112 CH32-F-C6H4-CH2H113 CH33-F-C6H4-CH2H114 CH34-F-C6H4-CH2H115 CH32-Cl-C6H4-CH2H116 CH33-Cl-C6H4-CH2H117 CH34-Cl-C6H4-CH2H118 CH32-Br-C6H4-CH2H119 CH33-Br-C6H4-CH2H120 CH34-Br-C6H4-CH2H121 CH32-CH3-C6H4-CH2H122 CH33-CH3-C6H4-CH2H123 CH34-CH3-C6H4-CH2H124 CH32-CF3-C6H4-CH2H125 CH33-CF3-C6H4-CH2H126 CH34-CF3-C6H4-CH2H127 CH32-i-C3H7-C6H4-CH2H128CH33-i-C3H7-C6H4-CH2H129CH34-i-C3H7-C6H4-CH2H130CH32-t-C4H9-C6H4-CH2H131CH33-t-C4H9-C6H4-CH2H132CH34-t-C4H9-C6H4-CH2H133CH32-CH3O-C6H4-CH2H134CH33-CH3O-C6H4-CH2H135CH34-CH3O-C6H4-CH2H136CH32-氰基-C6H4-CH2H137CH33-氰基-C6H4-CH2H138CH34-氰基-C6H4-CH2H139CH32-硝基-C6H4-CH2H140CH33-硝基-C6H4-CH2H141CH34-硝基-C6H4-CH2H142CH32，4-Cl2-C6H3-CH2H143CH33，4-Cl2-C6H3-CH2H144CH33，5-Cl2-C6H3-CH2H145CH32，6-Cl2-C6H3-CH2H146CH32，4-(CH3)2-C6H3-CH2H147CH32，5-(CH3)2-C6H3-CH2H148CH33，4-(CH3)2-C6H3-CH2H149CH33，5-(CH3)2-C6H3-CH2H150CH31-萘基-CH2H151CH32-萘基-CH2H152CH3C6H5-CH(CH3) H153CH32-Cl-C6H4-CH(CH3) H154CH33-Cl-C6H4-CH(CH3) H155CH34-Cl-C6H4-CH(CH3) H156CH3CH3-C6H4-CH(CH3) H157CH33-CH3-C6H4-CH(CH3)H158CH34-CH3-C6H4-CH(CH3)H159CH32-CF3-C6H4-CH(CH3)H160CH33-CF3-C6H4-CH(CH3)H161CH34-CF3-C6H4-CH(CH3)H162CH32-t-C4H9-C6H4-CH(CH3)H163CH33-t-C4H9-C6H4-CH(CH3)H164CH34-t-C4H9-C6H4-CH(CH3)H165CH32-CH3O-C6H4-CH(CH3) H166CH33-CH3O-C6H4-CH(CH3) H167CH34-CH3O-C6H4-CH(CH3) H168CH32-氰基-C6H4-CH(CH3)H169CH33-氰基-C6H4-CH(CH3)H170CH34-氰基-C6H4-CH(CH3)H171CH32，4-Cl2-C6H3-CH(CH3) H172CH33，4-Cl2-C6H3-CH(CH3) H173CH33，5-Cl2-C6H3-CH(CH3) H174CH32，4-(CH3)2-C6H3-CH(CH3) H175CH32，5-(CH3)2-C6H3-CH(CH3) H176CH3CH3OOC-CH2H177CH3C2H5OOC-CH2H178CH3i-C3H7OOC-CH2H179CH3t-C4H9OOC-CH2H180CH3t-C4H9OOC-CH(CH3) H181CH3N≡C-CH2H182CH3C6H5CO-CH2H183CH3吡啶-2-基-甲基 H184CH3吡嗪-2-基-甲基 H185CH3嘧啶-2-基-甲基 H186CH3呋喃-2-基-甲基 H187CH3吡咯-2-基-甲基 H188CH3N-甲基-吡咯-2-基-甲基 H189CH3噻吩-2-基-甲基 H190CH3異噁唑-5-基-甲基H191CH3噻唑-2-基-甲基 H192CH3噻唑-5-基-甲基 H193CH3噁唑-2-基-甲基 H194CH3吡唑-3-基-甲基 H195CH3苯并呋喃-2-基-甲基 H196CH3吲哚-2-基-甲基 H197CH3吲哚-3-基-甲基 H198CH3苯并噻唑-2-基-甲基 H199CH3喹啉-2-基-甲基 H200CH34-Cl-C6H4OCH(CH3)-CH2H201H HC2H5202H CH3C2H5203H t-C4H9C2H5204H CH2＝CH-CH2C2H5205H CH2＝C(-Cl)-CH2C2H5206H CH2＝C(CH3)-CH2C2H5207H CH3CH＝CH-CH2C2H5208H HC≡CCH2C2H5209H CH3C≡C-CH2C2H5210H 環(huán)-C6H11C2H5211H C6H5-CH2C2H5212H 2-F-C6H4-CH2C2H5213H 3-F-C6H4-CH2C2H5214H 4-F-C6H4-CH2C2H5215H 2-Cl-C6H4-CH2C2H5216H 3-Cl-C6H4-CH2C2H5217H 4-Cl-C6H4-CH2C2H5218H 2-Br-C6H4-CH2C2H5219H 3-Br-C6H4-CH2C2H5220H 4-Br-C6H4-CH2C2H5221H 2-CH3-C6H4-CH2C2H5222H3-CH3-C6H4-CH2C2H5223H4-CH3-C6H4-CH2C2H5224H2-CF3-C6H4-CH2C2H5225H3-CF3-C6H4-CH2C2H5226H4-CF3-C6H4-CH2C2H5227H2-i-C3H7-C6H4-CH2C2H5228H3-i-C3H7-C6H4-CH2C2H5229H4-i-C3H7-C6H4-CH2C2H5230H2-t-C4H9-C6H4-CH2C2H5231H3-t-C4H9-C6H4-CH2C2H5232H4-t-C4H9-C6H4-CH2C2H5233H2-CH3O-C6H4-CH2C2H5234H3-CH3O-C6H4-CH2C2H5235H4-CH3O-C6H4-CH2C2H5236H2-氰基-C6H4-CH2C2H5237H3-氰基-C6H4-CH2C2H5238H4-氰基-C6H4-CH2C2H5239H2-硝基-C6H4-CH2C2H5240H3-硝基-C6H4-CH2C2H5241H4-硝基-C6H4-CH2C2H5242H2，4-Cl2-C6H3-CH2C2H5243H3，4-Cl2-C6H3-CH2C2H5244H3，5-Cl2-C6H3-CH2C2H5245H2，6-Cl2-C6H3-CH2C2H5246H2，4-(CH3)2-C6H3-CH2C2H5247H2，5-(CH3)2-C6H3-CH2C2H5248H3，4-(CH3)2-C6H3-CH2C2H5249H3，5-(CH3)2-C6H3-CH2C2H5250H1-萘基-CH2C2H5251H2-萘基-CH2C2H5252HC6H5-CH(CH3)C2H5253H2-Cl-C6H4-CH(CH3) C2H5254H3-Cl-C6H4-CH(CH3) C2H5255H4-Cl-C6H4-CH(CH3) C2H5256H2-CH3-C6H4-CH(CH3) C2H5257H3-CH3-C6H4-CH(CH3) C2H5258H4-CH3-C6H4-CH(CH3) C2H5259H2-CF3-C6H4-CH(CH3) C2H5260H3-CF3-C6H4-CH(CH3) C2H5261H4-CF3-C6H4-CH(CH3) C2H5262H2-t-C4H9-C6H4-CH(CH3) C2H5263H3-t-C4H9-C6H4-CH(CH3) C2H5264H4-t-C4H9-C6H4-CH(CH3) C2H5265H2-CH3O-C6H4-CH(CH3)C2H5266H3-CH3O-C6H4-CH(CH3)C2H5267H4-CH3O-C6H4-CH(CH3)C2H5268H2-氰基-C6H4-CH(CH3) C2H5269 H3-氰基-C6H4-CH(CH3)C2H5270 H4-氰基-C6H4-CH(CH3)C2H5271 H2，4-Cl2-C6H3-CH(CH3) C2H5272 H3，4-Cl2-C6H3-CH(CH3) C2H5273 H3，5-Cl2-C6H3-CH(CH3) C2H5274 H2，4-(CH3)2-C6H3-CH(CH3) C2H5275 H2，5-(CH3)2-C6H3-CH(CH3) C2H5276 HCH3OOC-CH2C2H5277 HC2H5OOC-CH2C2H5278 Hi-C3H7OOC-CH2C2H5279 Ht-C4H9OOC-CH2C2H5280 Ht-C4H9OOC-CH(CH3) C2H5281 HN≡C-CH2C2H5282 HC6H5CO-CH2C2H5283 H吡啶-2-基-甲基 C2H5284 H吡嗪-2-基-甲基 C2H5285 H嘧啶-2-基-甲基 C2H5286 H呋喃-2-基-甲基 C2H5287 H吡咯-2-基-甲基 C2H5288 HN-甲基-吡咯-2-基-甲基 C2H5289 H噻吩-2-基-甲基 C2H5290 H異噁唑-5-基-甲基C2H5291 H噻唑-2-基-甲基 C2H5292 H噻唑-5-基-甲基 C2H5293 H噁唑-2-基-甲基 C2H5294 H吡唑-3-基-甲基 C2H5295 H苯并呋喃-2-基-甲基 C2H5296 H吲哚-2-基-甲基 C2H5297 H吲哚-3-基-甲基 C2H5298 H苯并噻唑-2-基-甲基 C2H5299 H喹啉-2-基-甲基 C2H5300 H4-Cl-C6H4OCH(CH3)-CH2C2H5301 CH3H C2H5302 CH3CH3C2H5303 CH3t-C4H9C2H5304 CH3CH2＝CH-CH2C2H5305 CH3CH2＝C(-Cl)-CH2C2H5306 CH3CH2＝C(CH3)-CH2C2H5307 CH3CH3CH＝CH-CH2C2H5308 CH3HC≡CCH2C2H5309 CH3CH3C≡C-CH2C2H5310 CH3環(huán)-C6H11C2H5311 CH3C6H5-CH2C2H5332 CH32-F-C6H4-CH2C2H5313 CH33-F-C6H4-CH2C2H5314 CH34-F-C6H4-CH2C2H5315 CH32-Cl-C6H4-CH2C2H5316CH33-Cl-C6H4-CH2C2H5317CH34-Cl-C6H4-CH2C2H5318CH32-Br-C6H4-CH2C2H5319CH33-Br-C6H4-CH2C2H5320CH34-Br-C6H4-CH2C2H5321CH32-CH3-C6H4-CH2C2H5322CH33-CH3-C5H4-CH2C2H5323CH34-CH3-C6H4-CH2C2H5324CH32-CF3-C6H4-CH2C2H5325CH33-CF3-C6H4-CH2C2H5326CH34-CF3-C6H4-CH2C2H5327CH32-i-C3H7-C6H4-CH2C2H5328CH33-i-C3H7-C6H4-CH2C2H5329CH34-i-C3H7-C6H4-CH2C2H5330CH32-t-C4H9-C6H4-CH2C2H5331CH33-t-C4H9-C6H4-CH2C2H5332CH34-t-C4H9-C6H4-CH2C2H5333CH32-CH3O-C6H4-CH2C2H5334CH33-CH3O-C6H4-CH2C2H5335CH34-CH3O-C6H4-CH2C2H5336CH32-氰基-C6H4-CH2C2H5337CH33-氰基-C6H4-CH2C2H5338CH34-氰基-C6H4-CH2C2H5339CH32-硝基-C6H4-CH2C2H5340CH33-硝基-C6H4-CH2C2H5341CH34-硝基-C6H4-CH2C2H5342CH32，4-Cl2-C6H3-CH2C2H5343CH33，4-Cl2-C6H3-CH2C2H5344CH33，5-Cl2-C6H3-CH2C2H5345CH32，6-Cl2-C6H3-CH2C2H5346CH32，4-(CH3)2-C6H3-CH2C2H5347CH32，5-(CH3)2-C6H3-CH2C2H5348CH33，4-(CH3)2-C6H3-CH2C2H5349CH33，5-(CH3)2-C6H3-CH2C2H5350CH31-萘基-CH2C2H5351CH32-萘基-CH2C2H5352CH3C6H5-CH(CH3)C2H5353CH32-Cl-C6H4-CH(CH3) C2H5354CH33-Cl-C6H4-CH(CH3) C2H5355CH34-Cl-C6H4-CH(CH3) C2H5356CH32-CH3-C6H4-CH(CH3) C2H5357CH33-CH3-C6H4-CH(CH3) C2H5358CH34-CH3-C6H4-CH(CH3) C2H5359CH32-CF3-C6H4-CH(CH3) C2H5360CH33-CF3-C6H4-CH(CH3) C2H5361CH34-CF3-C6H4-CH(CH3) C2H5362CH32-t-C4H9-C6H4-CH(CH3) C2H5363CH33-t-C4H9-C6H4-CH(CH3)C2H5364CH34-t-C4H9-C6H4-CH(CH3)C2H5365CH32-CH3O-C6H4-CH(CH3) C2H5366CH33-CH3O-C6H4-CH(CH3) C2H5367CH34-CH3O-C6H4-CH(CH3) C2H5368CH32-氰基-C6H4-CH(CH3)C2H5369CH33-氰基-C6H4-CH(CH3)C2H5370CH34-氰基-C6H4-CH(CH3)C2H5371CH32，4-Cl2-C6H3-CH(CH3) C2H5372CH33，4-Cl2-C6H3-CH(CH3) C2H5373CH33，5-Cl2-C6H3-CH(CH3) C2H5374CH32，4-(CH3)2-C6H3-CH(CH3) C2H5375CH32，5-(CH3)2-C6H3-CH(CH3) C2H5376CH3CH3OOC-CH2C2H5377CH3C2H5OOC-CH2C2H5378CH3i-C3H7OOC-CH2C2H5379CH3t-C4H9OOC-CH2C2H5380CH3t-C4H9OOC-CH(CH3) C2H5381CH3N≡C-CH2C2H5382CH3C6H5CO-CH2C2H5383CH3吡啶-2-基-甲基 C2H5384CH3吡嗪-2-基-甲基 C2H5385CH3嘧啶-2-基-甲基 C2H5386CH3呋喃-2-基-甲基 C2H5387CH3吡咯-2-基-甲基 C2H5388CH3N-甲基-吡咯-2-基-甲基 C2H5389CH3噻吩-2-基-甲基 C2H5390CH3異噁唑-5-基-甲基 C2H5391CH3噻唑-2-基-甲基 C2H5392CH3噻唑-5-基-甲基 C2H5393CH3噁唑-2-基-甲基 C2H5394CH3吡唑-3-基-甲基 C2H5395CH3苯并呋喃-2-基-甲基 C2H5396CH3吲哚-2-基-甲基 C2H5397CH3吲哚-3-基-甲基 C2H5398CH3苯并噻唑-2-基-甲基 C2H5399CH3喹啉-2-基-甲基 C2H5400CH34-Cl-C6H4OCH(CH3)-CH2C2H5
表5 化合物編號(hào)R1R21 HH2 HCH33 Ht-C4H94 HCH2＝CH-CH25 HCH2＝C(-Cl)-CH26 HCH2＝C(CH3)-CH27 HCH3CH＝CH-CH28 HHC≡CCH29 HCH3C≡C-CH210H環(huán)-C6H1111HC6H5-CH212H2-F-C6H4-CH213H3-F-C6H4-CH214H4-F-C6H4-CH215H2-Cl-C6H4-CH216H3-Cl-C6H4-CH217H4-Cl-C6H4-CH218H2-Br-C6H4-CH219H3-Br-C6H4-CH220H4-Br-C6H4-CH221H2-CH3-C6H4-CH222H3-CH3-C6H4-CH223H4-CH3-C6H4-CH224H2-CF3-C6H4-CH225H3-CF3-C6H4-CH226H4-CF3-C6H4-CH227H2-i-C3H7-C6H4-CH228H3-i-C3H7-C6H4-CH229H4-i-C3H7-C6H4-CH230H2-t-C4H9-C6H4-CH231H3-t-C4H9-C6H4-CH232H4-t-C4H9-C6H4-CH233H2-CH3O-C6H4-CH234H3-CH3O-C6H4-CH235H4-CH3O-C6H4-CH236H2-氰基-C6H4-CH237H3-氰基-C6H4-CH238H4-氰基-C6H4-CH239H2-硝基-C6H4-CH240H3-硝基-C6H4-CH241H4-硝基-C6H4-CH242H2，4-Cl2-C6H3-CH243H3，4-Cl2-C6H3-CH244H3，5-Cl2-C6H3-CH245H2，6-Cl2-C6H3-CH246H2，4-(CH3)2-C6H3-CH247H2，5-(CH3)2-C6H3-CH248H3，4-(CH3)2-C6H3-CH249H3，5-(CH3)2-C6H3-CH250H1-萘基-CH251H2-萘基-CH252HC6H5-CH(CH3)53H2-Cl-C6H4-CH(CH3)54H3-Cl-C6H4-CH(CH3)55H4-Cl-C6H4-CH(CH3)56H2-CH3-C6H4-CH(CH3)57H3-CH3-C6H4-CH(CH3)58H4-CH3-C6H4-CH(CH3)59H2-CF3-C6H4-CH(CH3)60H3-CF3-C6H4-CH(CH3)61H4-CF3-C6H4-CH(CH3)62H2-t-C4H9-C6H4-CH(CH3)63H3-t-C4H9-C6H4-CH(CH3)64H4-t-C4H9-C6H4-CH(CH3)65H2-CH3O-C6H4-CH(CH3)66H3-CH3O-C6H4-CH(CH3)67H4-CH3O-C6H4-CH(CH3)68H2-氰基-C6H4-CH(CH3)69H3-氰基-C6H4-CH(CH3)70H4-氰基-C6H4-CH(CH3)71H2，4-Cl2-C6H3-CH(CH3)72H3，4-Cl2-C6H3-CH(CH3)73H3，5-Cl2-C6H3-CH(CH3)74H2，4-(CH3)2-C6H3-CH(CH3)75H2，5-(CH3)2-C6H3-CH(CH3)76HCH3OOC-CH277HC2H5OOC-CH278Hi-C3H7OOC-CH279Ht-C4H9OOC-CH280Ht-C4H9OOC-CH(CH3)81HN≡C-CH282 H C6H5CO-CH283 H 吡啶-2-基-甲基84 H 吡嗪-2-基-甲基85 H 嘧啶-2-基-甲基86 H 呋喃-2-基-甲基87 H 吡咯-2-基-甲基88 H N-甲基-吡咯-2-基-甲基89 H 噻吩-2-基-甲基90 H 異噁唑-5-基-甲基91 H 噻唑-2-基-甲基92 H 噻唑-5-基-甲基93 H 噁唑-2-基-甲基94 H 吡唑-3-基-甲基95 H 苯并呋喃-2-基-甲基96 H 吲哚-2-基-甲基97 H 吲哚-3-基-甲基98 H 苯并噻唑-2-基-甲基99 H 喹啉-2-基-甲基100 H 4-Cl-C6H4OCH(CH3)-CH2101 CH3H102 CH3CH3103 CH3t-C4H9104 CH3CH2＝CH-CH2105 CH3CH2＝C(-Cl)-CH2106 CH3C(CH3)-CH2107 CH3CH3CH＝CH-CH2108 CH3HC≡CCH2109 CH3CH3C≡C-CH2110 CH3環(huán)o-C6H11111 CH3C6H5-CH2112 CH32-F-C6H4-CH2113 CH33-F-C6H4-CH2114 CH34-F-C6H4-CH2115 CH32-Cl-C6H4-CH2116 CH33-Cl-C6H4-CH2117 CH34-Cl-C6H4-CH2118 CH32-Br-C6H4-CH2119 CH33-Br-C6H4-CH2120 CH34-Br-C6H4-CH2121 CH32-CH3-C6H4-CH2122 CH33-CH3-C6H4-CH2123 CH34-CH3-C6H4-CH2124 CH32-CF3-C6H4-CH2125 CH33-CF3-C6H4-CH2126 CH34-CF3-C6H4-CH2127 CH32-i-C3H7-C6H4-CH2128 CH33-i-C3H7-C6H4-CH2129CH34-i-C3H7-C6H4-CH2130CH32-t-C4H9-C6H4-CH2131CH33-t-C4H9-C6H4-CH2132CH34-t-C4H9-C6H4-CH2133CH32-CH3O-C6H4-CH2134CH33-CH3O-C6H4-CH2135CH34-CH3O-C6H4-CH2136CH32-氰基-C6H4-CH2137CH33-氰基-C6H4-CH2138CH34-氰基-C6H4-CH2139CH32-硝基-C6H4-CH2140CH33-硝基-C6H4-CH2141CH34-硝基-C6H4-CH2142CH32，4-Cl2-C6H3-CH2143CH33，4-Cl2-C6H3-CH2144CH33，5-Cl2-C6H3-CH2145CH32，6-Cl2-C6H3-CH2146CH32，4-(CH3)2-C6H3-CH2147CH32，5-(CH3)2-C6H3-CH2148CH33，4-(CH3)2-C6H3-CH2149CH33，5-(CH3)2-C6H3-CH2150CH31-萘基-CH2151CH32-萘基-CH2152CH3C6H5-CH(CH3)153CH32-Cl-C6H4-CH(CH3)154CH33-Cl-C6H4-CH(CH3)155CH34-Cl-C6H4-CH(CH3)156CH3CH3-C6H4-CH(CH3)157CH33-CH3-C6H4-CH(CH3)158CH34-CH3-C6H4-CH(CH3)159CH32-CF3-C6H4-CH(CH3)160CH33-CF3-C6H4-CH(CH3)161CH34-CF3-C6H4-CH(CH3)162CH32-t-C4H9-C6H4-CH(CH3)163CH33-t-C4H9-C6H4-CH(CH3)164CH34-t-C4H9-C6H4-CH(CH3)165CH32-CH3O-C6H4-CH(CH3)166CH33-CH3O-C6H4-CH(CH3)167CH34-CH3O-C6H4-CH(CH3)168CH32-氰基-C6H4-CH(CH3)169CH33-氰基-C6H4-CH(CH3)170CH34-氰基-C6H4-CH(CH3)171CH32，4-Cl2-C6H3-CH(CH3)172CH33，4-Cl2-C6H3-CH(CH3)173CH33，5-Cl2-C6H3-CH(CH3)174CH32，4-(CH3)2-C6H3-CH(CH3)175CH32，5-(CH3)2-C6H3-C(CH3)2176CH3CH3OOC-CH2177CH3C2H5OOC-CH2178CH3i-C3H7OOC-CH2179CH3t-C4H9OOC-CH2180CH3t-C4H9OOC-CH(CH3)181CH3N≡C-CH2182CH3C6H5CO-CH2183CH3吡啶-2-基-甲基184CH3吡嗪-2-基-甲基185CH3嘧啶-2-基-甲基186CH3呋喃-2-基-甲基187CH3吡咯-2-基-甲基188CH3N-甲基-吡咯-2-基-甲基189CH3噻吩-2-基-甲基190CH3異噁唑-5-基-甲基191CH3噻唑-2-基-甲基192CH3噻唑-5-基-甲基193CH3噁唑-2-基-甲基194CH3吡唑-3-基-甲基195CH3苯并呋喃-2-基-甲基196CH3吲哚-2-基-甲基197CH3吲哚-3-基-甲基198CH3苯并噻唑-2-基-甲基199CH3喹啉-2-基-甲基200CH34-Cl-C6H4OCH(CH3)-CH2
表6 化合物編號(hào)R1R2R4R61 H H HH2 H CH3HH3 H t-C4H9HH4 H CH2＝CH-CH2HH5 H CH2＝C(-Cl)-CH2HH6 H CH2＝C(CH3)-CH2HH7 H CH3CH＝CH-CH2HH8 H HC≡CCH2HH9 H CH3C≡C-CH2HH10H 環(huán)-C6H11HH11H C6H5-CH2HH12H 2-F-C6H4-CH2HH13H 3-F-C6H4-CH2HH14H 4-F-C6H4-CH2HH15H 2-Cl-C6H4-CH2HH16H 3-Cl-C6H4-CH2HH17H 4-Cl-C6H4-CH2HH18H 2-Br-C6H4-CH2HH19H 3-Br-C6H4-CH2HH20H 4-Br-C6H4-CH2HH21H 2-CH3-C6H4-CH2HH22H 3-CH3-C6H4-CH2HH23H 4-CH3-C6H4-CH2HH24H 2-CF3-C6H4-CH2HH25H 3-CF3-C6H4-CH2HH26H 4-CF3-C6H4-CH2HH27H 2-i-C3H7-C6H4-CH2HH28H 3-i-C3H7-C6H4-CH2HH29H 4-i-C3H7-C6H4-CH2HH30H 2-t-C4H9-C6H4-CH2HH31H 3-t-C4H9-C6H4-CH2HH32H 4-t-C4H9-C6H4-CH2HH33H 2-CH3O-C6H4-CH2HH34H 3-CH3O-C6H4-CH2HH35H 4-CH3O-C6H4-CH2HH36H2-氰基-C6H4-CH2HH37H3-氰基-C6H4-CH2HH38H4-氰基-C6H4-CH2HH39H2-硝基-C6H4-CH2HH40H3-硝基-C6H4-CH2HH41H4-硝基-C6H4-CH2HH42H2，4-Cl2-C6H3-CH2HH43H3，4-Cl2-C6H3-CH2HH44H3，5-Cl2-C6H3-CH2HH45H2，6-Cl2-C6H3-CH2HH46H2，4-(CH3)2-C6H3-CH2HH47H2，5-(CH3)2-C6H3-CH2HH48H3，4-(CH3)2-C6H3-CH2HH49H3，5-(CH3)2-C6H3-CH2HH50H1-萘基-CH2HH51H2-萘基-CH2HH52HC6H5-CH(CH3) HH53H2-Cl-C6H4-CH(CH3) HH54H3-Cl-C6H4-CH(CH3) HH55H4-Cl-C6H4-CH(CH3) HH56H2-CH3-C6H4-CH(CH3) HH57H3-CH3-C6H4-CH(CH3) HH58H4-CH3-C6H4-CH(CH3) HH59H2-CF3-C6H4-CH(CH3) HH60H3-CF3-C6H4-CH(CH3) HH61H4-CF3-C6H4-CH(CH3) HH62H2-t-C4H9-C6H4-CH(CH3) HH63H3-t-C4H9-C6H4-CH(CH3) HH64H4-t-C4H9-C6H4-CH(CH3) HH65H2-CH3O-C6H4-CH(CH3) HH66H3-CH3O-C6H4-CH(CH3) HH67H4-CH3O-C6H4-CH(CH3) HH68H2-氰基-C6H4-CH(CH3) HH69H3-氰基-C6H4-CH(CH3) HH70H4-氰基-C6H4-CH(CH3) HH71H2，4-Cl2-C6H3-CH(CH3)HH72H3，4-Cl2-C6H3-CH(CH3)HH73H3，5-Cl2-C6H3-CH(CH3)HH74H2，4-(CH3)2-C6H3-CH(CH3)HH75H2，5-(CH3)2-C6H3-CH(CH3)HH76HCH3OOC-CH2HH77HC2H5OOC-CH2HH78Hi-C3H7OOC-CH2HH79Ht-C4H9OOC-CH2HH80Ht-C4H9OOC-CH(CH3) HH81HN≡C-CH2HH82HC6H5CO-CH2HH83 H 吡啶-2-基-甲基HH84 H 吡嗪-2-基-甲基HH85 H 嘧啶-2-基-甲基HH86 H 呋喃-2-基-甲基HH87 H 吡咯-2-基-甲基HH88 H N-甲基-吡咯-2-基-甲基 HH89 H 噻吩-2-基-甲基HH90 H 異噁唑-5-基-甲基 HH91 H 噻唑-2-基-甲基HH92 H 噻唑-5-基-甲基HH93 H 噁唑-2-基-甲基HH94 H 吡唑-3-基-甲基HH95 H 苯并呋喃-2-基-甲基HH96 H 吲哚-2-基-甲基HH97 H 吲哚-3-基-甲基HH98 H 苯并噻唑-2-基-甲基HH99 H 喹啉-2-基-甲基HH100H 4-Cl-C6H4OCH(CH3)-CH2HH101CH3H HH102CH3CH3HH103CH3t-C4H9HH104CH3CH2＝CH-CH2HH105CH3CH2＝C(-Cl)-CH2HH106CH3C(CH3)-CH2HH107CH3CH3CH＝CH-CH2HH108CH3HC≡CCH2HH109CH3CH3C≡C-CH2HH110CH3環(huán)C-C6H11HH111CH3C6H5-CH2HH112CH32-F-C6H4-CH2HH113CH33-F-C6H4-CH2HH114CH34-F-C6H4-CH2HH115CH32-Cl-C6H4-CH2HH116CH33-Cl-C6H4-CH2HH117CH34-Cl-C6H4-CH2HH118CH32-Br-C6H4-CH2HH119CH33-Br-C6H4-CH2HH120CH34-Br-C6H4-CH2HH121CH32-CH3-C6H4-CH2HH122CH33-CH3-C6H4-CH2HH123CH34-CH3-C6H4-CH2HH124CH32-CF3-C6H4-CH2HH125CH33-CF3-C6H4-CH2HH126CH34-CF3-C6H4-CH2HH127CH32-i-C3H7-C6H4-CH2HH128CH33-i-C3H7-C6H4-CH2HH129CH34-i-C3H7-C6H4-CH2HH130CH32-t-C4H9-C6H4-CH2H H131CH33-t-C4H9-C6H4-CH2H H132CH34-t-C4H9-C6H4-CH2H H133CH32-CH3O-C6H4-CH2H H134CH33-CH3O-C6H4-CH2H H135CH34-CH3O-C6H4-CH2H H136CH32-氰基-C6H4-CH2H H137CH33-氰基-C6H4-CH2H H138CH34-氰基-C6H4-CH2H H139CH32-硝基-C6H4-CH2H H140CH33-硝基-C6H4-CH2H H141CH34-硝基-C6H4-CH2H H142CH32，4-Cl2-C6H3-CH2H H143CH33，4-Cl2-C6H3-CH2H H144CH33，5-Cl2-C6H3-CH2H H145CH32，6-Cl2-C6H3-CH2H H146CH32，4-(CH3)2-C6H3-CH2H H147CH32，5-(CH3)2-C6H3-CH2H H148CH33，4-(CH3)2-C6H3-CH2H H149CH33，5-(CH3)2-C6H3-CH2H H150CH31-萘基氰-CH2H H151CH32-萘基1-CH2H H152CH3C6H5-CH(CH3) H H153CH32-Cl-C6H4-CH(CH3)H H154CH33-Cl-C6H4-CH(CH3)H H155CH34-Cl-C6H4-CH(CH3)H H156CH3CH3-C6H4-CH(CH3)H H157CH33-CH3-C6H4-CH(CH3) H H158CH34-CH3-C6H4-CH(CH3) H H159CH32-CF3-C6H4-CH(CH3) H H160CH33-CF3-C6H4-CH(CH3) H H161CH34-CF3-C6H4-CH(CH3) H H162CH32-t-C4H9-C6H4-CH(CH3) H H163CH33-t-C4H9-C6H4-CH(CH3) H H164CH34-t-C4H9-C6H4-CH(CH3) H H165CH32-CH3O-C6H4-CH(CH3) H H166CH33-CH3O-C6H4-CH(CH3) H H167CH34-CH3O-C6H4-CH(CH3) H H168CH32-氰基-C6H4-CH(CH3) H H169CH33-氰基-C6H4-CH(CH3) H H170CH34-氰基-C6H4-CH(CH3) H H171CH32，4-Cl2-C6H3-CH(CH3) H H172CH33，4-Cl2-C6H3-CH(CH3) H H173CH33，5-Cl2-C6H3-CH(CH3) H H174CH32，4-(CH3)2-C6H3-CH(CH3) H H175CH32，5-(CH3)2-C6H3-CH(CH3) H H176CH3CH3OOC-CH2H H177 CH3C2H5OOC-CH2HH178 CH3i-C3H7OOC-CH2HH179 CH3t-C4H9OOC-CH2HH180 CH3t-C4H9OOC-CH(CH3) HH181 CH3N≡C-CH2HH182 CH3C6H5CO-CH2HH183 CH3吡啶-2-基-甲基 HH184 CH3吡嗪-2-基-甲基 HH185 CH3嘧啶-2-基-甲基 HH186 CH3呋喃-2-基-甲基 HH187 CH3吡咯-2-基-甲基 HH188 CH3N-甲基-吡咯-2-基-甲基 HH189 CH3噻吩-2-基-甲基 HH190 CH3異噁唑-5-基-甲基 HH191 CH3噻唑-2-基-甲基 HH192 CH3噻唑-5-基-甲基 HH193 CH3噁唑-2-基-甲基 HH194 CH3吡唑-3-基-甲基 HH195 CH3苯并呋喃-2-基-甲基 HH196 CH3引哚-2-基-甲基 HH197 CH3吲哚-3-基-甲基 HH198 CH3苯并噻唑-2-基-甲基 HH199 CH3喹啉-2-基-甲基 HH200 CH34-Cl-C6H4OCH(CH3)-CH2HH201 H H C2H5H202 H CH3C2H5H203 H t-C4H9C2H5H204 H CH2＝CH-CH2C2H5H205 H CH2＝C(-Cl)-CH2C2H5H206 H CH2＝C(CH3)-CH2C2H5H207 H CH3CH＝CH-CH2C2H5H208 H HC≡CCH2C2H5H209 H CH3C≡C-CH2C2H5H210 H 環(huán)-C6H11C2H5H211 H C6H5-CH2C2H5H212 H 2-F-C6H4-CH2C2H5H213 H 3-F-C6H4-CH2C2H5H214 H 4-F-C6H4-CH2C2H5H215 H 2-Cl-C6H4-CH2C2H5H216 H 3-Cl-C6H4-CH2C2H5H217 H 4-Cl-C6H4-CH2C2H5H218 H 2-Br-C6H4-CH2C2H5H219 H 3-Br-C6H4-CH2C2H5H220 H 4-Br-C6H4-CH2C2H5H221 H 2-CH3-C6H4-CH2C2H5H222 H 3-CH3-C6H4-CH2C2H5H223 H 4-CH3-C6H4-CH2C2H5H224 H2-CF3-C6H4-CH2C2H5H225 H3-CF3-C6H4-CH2C2H5H226 H4-CF3-C6H4-CH2C2H5H227 H2-i-C3H7-C6H4-CH2C2H5H228 H3-i-C3H7-C6H4-CH2C2H5H229 H4-i-C3H7-C6H4-CH2C2H5H230 H2-t-C4H9-C6H4-CH2C2H5H231 H3-t-C4H9-C6H4-CH2C2H5H232 H4-t-C4H9-C6H4-CH2C2H5H233 H2-CH3O-C6H4-CH2C2H5H234 H3-CH3O-C6H4-CH2C2H5H235 H4-CH3O-C6H4-CH2C2H5H236 H2-氰基-C6H4-CH2C2H5H237 H3-氰基-C6H4-CH2C2H5H238 H4-氰基-C6H4-CH2C2H5H239 H2-硝基-C6H4-CH2C2H5H240 H3-硝基-C6H4-CH2C2H5H241 H4-硝基-C6H4-CH2C2H5H242 H2，4-Cl2-C6H3-CH2C2H5H243 H3，4-Cl2-C6H3-CH2C2H5H244 H3，5-Cl2-C6H3-CH2C2H5H245 H2，6-Cl2-C6H3-CH2C2H5H246 H2，4-(CH3)2-C6H3-CH2C2H5H247 H2，5-(CH3)2-C6H3-CH2C2H5H248 H3，4-(CH3)2-C6H3-CH2C2H5H249 H3，5-(CH3)2-C6H3-CH2C2H5H250 H1-萘基-CH2C2H5H251 H2-萘基-CH2C2H5H252 HC6H5-CH(CH3)C2H5H253 H2-Cl-C6H4-CH(CH3) C2H5H254 H3-Cl-C6H4-CH(CH3) C2H5H255 H4-Cl-C6H4-CH(CH3) C2H5H256 H2-CH3-C6H4-CH(CH3) C2H5H257 H3-CH3-C6H4-CH(CH3) C2H5H258 H4-CH3-C6H4-CH(CH3) C2H5H259 H2-CF3-C6H4-CH(CH3) C2H5H260 H3-CF3-C6H4-CH(CH3) C2H5H261 H4-CF3-C6H4-CH(CH3) C2H5H262 H2-t-C4H9-C6H4-CH(CH3) C2H5H263 H3-t-C4H9-C6H4-CH(CH3) C2H5H264 H4-t-C4H9-C6H4-CH(CH3) C2H5H265 H2-CH3O-C6H4-CH(CH3)C2H5H266 H3-CH3O-C6H4-CH(CH3)C2H5H267 H4-CH3O-C6H4-CH(CH3)C2H5H268 H2-氰基-C6H4-CH(CH3) C2H5H269 H3-氰基-C6H4-CH(CH3) C2H5H270 H4-氰基-C6H4-CH(CH3) C2H5H271H2，4-Cl2-C6H3-CH(CH3)C2H5H272H 3，4-Cl2-C6H3-CH(CH3) C2H5H273H 3，5-Cl2-C6H3-CH(CH3) C2H5H274H 2，4-(CH3)2-C6H3-CH(CH3) C2H5H275H 2，5-(CH3)2-C6H3-CH(CH3) C2H5H276H CH3OOC-CH2C2H5H277H C2H5OOC-CH2C2H5H278H i-C3H7OOC-CH2C2H5H279H t-C4H9OOC-CH2C2H5H280H t-C4H9OOC-CH(CH3) C2H5H281H N≡C-CH2C2H5H282H C6H5CO-CH2C2H5H283H 吡啶-2-基-甲基 C2H5H284H 吡嗪-2-基-甲基 C2H5H285H 嘧啶-2-基-甲基 C2H5H286H 呋喃-2-基-甲基 C2H5H287H 吡咯-2-基-甲基 C2H5H288H N-甲基-吡咯-2-基-甲基 C2H5H289H 噻吩-2-基-甲基 C2H5H290H 異噁唑-5-基-甲基C2H5H291H 噻唑-2-基-甲基 C2H5H292H 噻唑-5-基-甲基 C2H5H293H 噁唑-2-基-甲基 C2H5H294H 吡唑-3-基-甲基 C2H5H295H 苯并呋喃-2-基-甲基 C2H5H296H 吲哚-2-基-甲基 C2H5H297H 吲哚-3-基-甲基 C2H5H298H 苯并噻唑-2-基-甲基 C2H5H299H 喹啉-2-基-甲基 C2H5H300H 4-Cl-C6H4OCH(CH3)-CH2C2H5H301CH3H C2H5H302CH3CH3C2H5H303CH3t-C4H9C2H5H304CH3CH2＝CH-CH2C2H5H305CH3CH2＝C(-Cl)-CH2C2H5H306CH3CH2＝C(CH3)-CH2C2H5H307CH3CH3CH＝CH-CH2C2H5H308CH3HC≡CCH2C2H5H309CH3CH3C≡C-CH2C2H5H310CH3環(huán)-C6H11C2H5H311CH3C6H5-CH2C2H5H332CH32-F-C6H4-CH2C2H5H313CH33-F-C6H4-CH2C2H5H314CH34-F-C6H4-CH2C2H5H316CH33-Cl-C6H4-CH2C2H5H317CH34-Cl-C6H4-CH2C2H5H318CH32-Br-C6H4-CH2C2H5H319CH33-Br-C6H4-CH2C2H5H320CH34-Br-C6H4-CH2C2H5H321CH32-CH3-C6H4-CH2C2H5H322CH33-CH3-C6H4-CH2C2H5H323CH34-CH3-C6H4-CH2C2H5H324CH32-CF3-C6H4-CH2C2H5H325CH33-CF3-C6H4-CH2C2H5H326CH34-CF3-C6H4-CH2C2H5H327CH32-i-C3H7-C6H4-CH2C2H5H328CH33-i-C3H7-C6H4-CH2C2H5H329CH34-i-C3H7-C6H4-CH2C2H5H330CH32-t-C4H9-C6H4-CH2C2H5H331CH33-t-C4H9-C6H4-CH2C2H5H332CH34-t-C4H9-C6H4-CH2C2H5H333CH32-CH3O-C6H4-CH2C2H5H334CH33-CH3O-C6H4-CH2C2H5H335CH34-CH3O-C6H4-CH2C2H5H336CH32-氰基-C6H4-CH2C2H5H337CH33-氰基-C6H4-CH2C2H5H338CH34-氰基-C6H4-CH2C2H5H339CH32-硝基-C6H4-CH2C2H5H340CH33-硝基-C6H4-CH2C2H5H341CH34-硝基-C6H4-CH2C2H5H342CH32，4-Cl2-C6H3-CH2C2H5H343CH33，4-Cl2-C6H3-CH2C2H5H344CH33，5-Cl2-C6H3-CH2C2H5H345CH32，6-Cl2-C6H3-CH2C2H5H346CH32，4-(CH3)2-C6H3-CH2C2H5H347CH32，5-(CH3)2-C6H3-CH2C2H5H348CH33，4-(CH3)2-C6H3-CH2C2H5H349CH33，5-(CH3)2-C6H3-CH2C2H5H350CH31-萘基-CH2C2H5H351CH32-萘基-CH2C2H5H352CH3C6H5-CH(CH3) C2H5H353CH32-Cl-C6H4-CH(CH3) C2H5H354CH33-Cl-C6H4-CH(CH3) C2H5H355CH34-Cl-C6H4-CH(CH3) C2H5H356CH32-CH3-C6H4-CH(CH3)C2H5H357CH33-CH3-C6H4-CH(CH3)C2H5H358CH34-CH3-C6H4-CH(CH3)C2H5H359CH32-CF3-C6H4-CH(CH3)C2H5H360CH33-CF3-C6H4-CH(CH3)C2H5H361CH34-CF3-C6H4-CH(CH3)C2H5H362CH32-t-C4H9-C6H4-CH(CH3)C2H5H363CH33-t-C4H9-C6H4-CH(CH3)C2H5H364CH34-t-C4H9-C6H4-CH(CH3)C2H5H365CH32-CH3O-C6H4-CH(CH3) C2H5H366CH33-CH3O-C6H4-CH(CH3) C2H5H367CH34-CH3O-C6H4-CH(CH3) C2H5H368CH32-氰基-C6H4-CH(CH3) C2H5H369CH33-氰基-C6H4-CH(CH3) C2H5H370CH34-氰基-C6H4-CH(CH3) C2H5H371CH32，4-Cl2-C6H3-CH(CH3)C2H5H372CH33，4-Cl2-C6H3-CH(CH3)C2H5H373CH33，5-Cl2-C6H3-CH(CH3)C2H5H374CH32，4-(CH3)2-C6H3-CH(CH3)C2H5H375CH32，5-(CH3)2-C6H3-CH(CH3)C2H5H376CH3CH3OOC-CH2C2H5H377CH3C2H5OOC-CH2C2H5H378CH3i-C3H7OOC-CH2C2H5H379CH3t-C4H9OOC-CH2C2H5H380CH3t-C4H9OOC-CH(CH3) C2H5H381CH3N≡C-CH2C2H5H382CH3C6H5CO-CH2C2H5H383CH3吡啶-2-基-甲基 C2H5H384CH3吡嗪-2-基-甲基 C2H5H385CH3嘧啶-2-基-甲基 C2H5H386CH3呋喃-2-基-甲基 C2H5H387CH3吡咯-2-基-甲基 C2H5H388CH3N-甲基-吡咯-2-基-甲基 C2H5H389CH3噻吩-2-基-甲基 C2H5H390CH3異噁唑-5-基-甲基 C2H5H391CH3噻唑-2-基-甲基 C2H5H392CH3噻唑-5-基-甲基 C2H5H393CH3噁唑-2-基-甲基 C2H5H394CH3吡唑-3-基-甲基 C2H5H395CH3苯并呋喃-2-基-甲基 C2H5H396CH3吲哚-2-基-甲基 C2H5H397CH3吲哚-3-基-甲基 C2H5H398CH3苯并噻唑-2-基-甲基 C2H5H399CH3喹啉-2-基-甲基 C2H5H400CH34-Cl-C6H4OCH(CH3)-CH2C2H5H401H H H CH3402H CH3H CH3403H t-C4H9H CH3404H CH2＝CH-CH2H CH3405H CH2＝C(-Cl)-CH2H CH3406H CH2＝C(CH3)-CH2H CH3407H CH3CH＝CH-CH2H CH3408H HC≡CCH2H CH3409H CH3C≡C-CH2H CH3410H 環(huán)-C6H11H CH3411H C6H5-CH2H CH3412H 2-F-C6H4-CH2H CH3413 H3-F-C6H4-CH2HCH3414 H4-F-C6H4-CH2HCH3415 H2-Cl-C6H4-CH2HCH3416 H3-Cl-C6H4-CH2HCH3417 H4-Cl-C6H4-CH2HCH3418 H2-Br-C6H4-CH2HCH3419 H3-Br-C6H4-CH2HCH3420 H4-Br-C6H4-CH2HCH3421 H2-CH3-C6H4-CH2HCH3422 H3-CH3-C6H4-CH2HCH3423 H4-CH3-C6H4-CH2HCH3424 H2-CF3-C6H4-CH2HCH3425 H3-CF3-C6H4-CH2HCH3426 H4-CF3-C6H4-CH2HCH3427 H2-i-C3H7-C6H4-CH2HCH3428 H3-i-C3H7-C6H4-CH2HCH3429 H4-i-C3H7-C6H4-CH2HCH3430 H2-t-C4H9-C6H4-CH2HCH3431 H3-t-C4H9-C6H4-CH2HCH3432 H4-t-C4H9-C6H4-CH2HCH3433 H2-CH3O-C6H4-CH2HCH3434 H3-CH3O-C6H4-CH2HCH3435 H4-CH3O-C6H4-CH2HCH3436 H2-氰基-C6H4-CH2HCH3437 H3-氰基-C6H4-CH2HCH3438 H4-氰基-C6H4-CH2HCH3439 H2-硝基-C6H4-CH2HCH3440 H3-硝基-C6H4-CH2HCH3441 H4-硝基-C6H4-CH2HCH3442 H2，4-Cl2-C6H3-CH2HCH3443 H3，4-Cl2-C6H3-CH2HCH3444 H3，5-Cl2-C6H3-CH2HCH3445 H2，6-Cl2-C6H3-CH2HCH3446 H2，4-(CH3)2-C6H3-CH2HCH3447 H2，5-(CH3)2-C6H3-CH2HCH3448 H3，4-(CH3)2-C6H3-CH2HCH3449 H3，5-(CH3)2-C6H3-CH2HCH3450 H1-萘基-CH2HCH3451 H2-萘基-CH2HCH3452 HC6H5-CH(CH3)HCH3453 H2-Cl-C6H4-CH(CH3) HCH3454 H3-Cl-C6H4-CH(CH3) HCH3455 H4-Cl-C6H4-CH(CH3) HCH3456 H2-CH3-C6H4-CH(CH3) HCH3457 H3-CH3-C6H4-CH(CH3) HCH3458 H4-CH3-C6H4-CH(CH3) HCH3459 H2-CF3-C6H4-CH(CH3) HCH3460 H 3-CF3-C6H4-CH(CH3) HCH3461 H 4-CF3-C6H4-CH(CH3) HCH3462 H 2-t-C4H9-C6H4-CH(CH3) HCH3463 H 3-t-C4H9-C6H4-CH(CH3) HCH3464 H 4-t-C4H9-C6H4-CH(CH3) HCH3465 H 2-CH3O-C6H4-CH(CH3)HCH3466 H 3-CH3O-C6H4-CH(CH3)HCH3467 H 4-CH3O-C6H4-CH(CH3)HCH3468 H 2-氰基-C6H4-CH(CH3) HCH3469 H 3-氰基-C6H4-CH(CH3) HCH3470 H 4-氰基-C6H4-CH(CH3) HCH3471 H 2，4-Cl2-C6H3-CH(CH3) HCH3472 H 3，4-Cl2-C6H3-CH(CH3) HCH3473 H 3，5-Cl2-C6H3-CH(CH3) HCH3474 H 2，4-(CH3)2-C6H3-CH(CH3) HCH3475 H 2，5-(CH3)2-C6H3-CH(CH3) HCH3476 H CH3OOC-CH2HCH3477 H C2H5OOC-CH2HCH3478 H i-C3H7OOC-CH2HCH3479 H t-C4H9OOC-CH2HCH3480 H t-C4H9OOC-CH(CH3)HCH3481 H N≡C-CH2HCH3482 H C6H5CO-CH2HCH3483 H 吡啶-2-基-甲基 HCH3484 H 吡嗪-2-基-甲基 HCH3485 H 嘧啶-2-基-甲基 HCH3486 H 呋喃-2-基-甲基 HCH3487 H 吡咯-2-基-甲基 HCH3488 H N-甲基-吡咯-2-基-甲基HCH3489 H 噻吩-2-基-甲基 HCH3490 H 異噁唑-5-基-甲基 HCH3491 H 噻唑-2-基-甲基 HCH3492 H 噻唑-5-基-甲基 HCH3493 H 噁唑-2-基-甲基 HCH3494 H 吡唑-3-基-甲基 HCH3495 H 苯并呋喃-2-基-甲基 HCH3496 H 吲哚-2-基-甲基 HCH3497 H 吲哚-3-基-甲基 HCH3498 H 苯并噻唑-2-基-甲基 HCH3499 H 喹啉-2-基-甲基 HCH3500 H 4-Cl-C6H4OCH(CH3)-CH2HCH3501 CH3HHCH3502 CH3CH3HCH3503 CH3t-C4H9HCH3504 CH3CH2＝CH-CH2HCH3505 CH3CH2＝C(-Cl)-CH2HCH3506 CH3C(CH3)-CH2HCH3507CH3CH3CH＝CH-CH2HCH3508CH3HC≡CCH2HCH3509CH3CH3C≡C-CH2HCH3510CH3環(huán)-C6H11HCH3511CH3C6H5-CH2HCH3512CH32-F-C6H4-CH2HCH3513CH33-F-C6H4-CH2HCH3514CH34-F-C6H4-CH2HCH3515CH32-Cl-C6H4-CH2HCH3516CH33-Cl-C6H4-CH2HCH3517CH34-Cl-C6H4-CH2HCH3518CH32-Br-C6H4-CH2HCH3519CH33-Br-C6H4-CH2HCH3520CH34-Br-C6H4-CH2HCH3521CH32-CH3-C6H4-CH2HCH3522CH33-CH3-C6H4-CH2HCH3523CH34-CH3-C6H4-CH2HCH3524CH32-CF3-C6H4-CH2HCH3525CH33-CF3-C6H4-CH2HCH3526CH34-CF3-C6H4-CH2HCH3527CH32-i-C3H7-C6H4-CH2HCH3528CH33-i-C3H7-C6H4-CH2HCH3529CH34-i-C3H7-C6H4-CH2HCH3530CH32-t-C4H9-C6H4-CH2HCH3531CH33-t-C4H9-C6H4-CH2HCH3532CH34-t-C4H9-C6H4-CH2HCH3533CH32-CH3O-C6H4-CH2HCH3534CH33-CH3O-C6H4-CH2HCH3535CH34-CH3O-C6H4-CH2HCH3536CH32-氰基-C6H4-CH2HCH3537CH33-氰基-C6H4-CH2HCH3538CH34-氰基-C6H4-CH2HCH3539CH32-Nitro-C6H4-CH2HCH3540CH33-Nitro-C6H4-CH2HCH3541CH34-Nitro-C6H4-CH2HCH3542CH32，4-Cl2-C6H3-CH2HCH3543CH33，4-Cl2-C6H3-CH2HCH3544CH33，5-Cl2-C6H3-CH2HCH3545CH32，6-Cl2-C6H3-CH2HCH3546CH32，4-(CH3)2-C6H3-CH2HCH3547CH32，5-(CH3)2-C6H3-CH2HCH3548CH33，4-(CH3)2-C6H3-CH2HCH3549CH33，5-(CH3)2-C6H3-CH2HCH3550CH31-萘基-CH2HCH3551CH32-萘基-CH2HCH3552CH3C6H5-CH(CH3) HCH3553CH32-Cl-C6H4-CH(CH3)HCH3554CH33-Cl-C6H4-CH(CH3) H CH3555CH34-Cl-C6H4-CH(CH3) H CH3556CH3CH3-C6H4-CH(CH3) H CH3557CH33-CH3-C6H4-CH(CH3)H CH3558CH34-CH3-C6H4-CH(CH3)H CH3559CH32-CF3-C6H4-CH(CH3)H CH3560CH33-CF3-C6H4-CH(CH3)H CH3561CH34-CF3-C6H4-CH(CH3)H CH3562CH32-t-C4H9-C6H4-CH(CH3)H CH3563CH33-t-C4H9-C6H4-CH(CH3)H CH3564CH34-t-C4H9-C6H4-CH(CH3)H CH3565CH32-CH3O-C6H4-CH(CH3) H CH3566CH33-CH3O-C6H4-CH(CH3) H CH3567CH34-CH3O-C6H4-CH(CH3) H CH3568CH32-氰基-C6H4-CH(CH3)H CH3569CH33-氰基-C6H4-CH(CH3)H CH3570CH34-氰基-C6H4-CH(CH3)H CH3571CH32，4-Cl2-C6H3-CH(CH3) H CH3572CH33，4-Cl2-C6H3-CH(CH3) H CH3573CH33，5-Cl2-C6H3-CH(CH3) H CH3574CH32，4-(CH3)2-C6H3-CH(CH3) H CH3575CH32，5-(CH3)2-C6H3-CH(CH3) H CH3576CH3CH3OOC-CH2H CH3577CH3C2H5OOC-CH2H CH3578CH3i-C3H7OOC-CH2H CH3579CH3t-C4H9OOC-CH2H CH3580CH3t-C4H9OOC-CH(CH3) H CH3581CH3N≡C-CH2H CH3582CH3C6H5CO-CH2H CH3583CH3吡啶-2-基-甲基 H CH3584CH3吡嗪-2-基-甲基 H CH3585CH3嘧啶-2-基-甲基 H CH3586CH3呋喃-2-基-甲基 H CH3587CH3吡咯-2-基-甲基 H CH3588CH3N-甲基-吡咯-2-基-甲基 H CH3589CH3噻吩-2-基-甲基 H CH3590CH3異噁唑-5-基-甲基H CH3591CH3噻唑-2-基-甲基 H CH3592CH3噻唑-5-基-甲基 H CH3593CH3噁唑-2-基-甲基 H CH3594CH3吡唑-3-基-甲基 H CH3595CH3苯并呋喃-2-基-甲基 H CH3596CH3吲哚-2-基-甲基 H CH3597CH3吲哚-3-基-甲基 H CH3598CH3苯并噻唑-2-基-甲基 H CH3599CH3喹啉-2-基-甲基 H CH3600CH34-Cl-C6H4OCH(CH3)-CH2H CH360lHH C2H5CH3602HCH3C2H5CH3603Ht-C4H9C2H5CH3604HCH2＝CH-CH2C2H5CH3605HCH2＝C(-Cl)-CH2C2H5CH3606HCH2＝C(CH3)-CH2C2H5CH3607HCH3CH＝CH-CH2C2H5CH3608HHC≡CCH2C2H5CH3609HCH3C≡C-CH2C2H5CH3610H環(huán)-C6H11C2H5CH3611HC6H5-CH2C2H5CH3612H2-F-C6H4-CH2C2H5CH3613H3-F-C6H4-CH2C2H5CH3614H4-F-C6H4-CH2C2H5CH3615H2-Cl-C6H4-CH2C2H5CH3616H3-Cl-C6H4-CH2C2H5CH3617H4-Cl-C6H4-CH2C2H5CH3618H2-Br-C6H4-CH2C2H5CH3619H3-Br-C6H4-CH2C2H5CH3620H4-Br-C6H4-CH2C2H5CH3621H2-CH3-C6H4-CH2C2H5CH3622H3-CH3-C6H4-CH2C2H5CH3623H4-CH3-C6H4-CH2C2H5CH3624H2-CF3-C6H4-CH2C2H5CH3625H3-CF3-C6H4-CH2C2H5CH3626H4-CF3-C6H4-CH2C2H5CH3627H2-i-C3H7-C6H4-CH2C2H5CH3628H3-i-C3H7-C6H4-CH2C2H5CH3629H4-i-C3H7-C6H4-CH2C2H5CH3630H2-t-C4H9-C6H4-CH2C2H5CH3631H3-t-C4H9-C6H4-CH2C2H5CH3632H4-t-C4H9-C6H4-CH2C2H5CH3633H2-CH3O-C6H4-CH2C2H5CH3634H3-CH3O-C6H4-CH2C2H5CH3635H4-CH3O-C6H4-CH2C2H5CH3636H2-氰基-C6H4-CH2C2H5CH3637H3-氰基-C6H4-CH2C2H5CH3638H4-氰基-C6H4-CH2C2H5CH3639H2-硝基-C6H4-CH2C2H5CH3640H3-硝基-C6H4-CH2C2H5CH3641H4-硝基-C6H4-CH2C2H5CH3642H2，4-Cl2-C6H3-CH2C2H5CH3643H3，4-Cl2-C6H3-CH2C2H5CH3644H3，5-Cl2-C6H3-CH2C2H5CH3645H2，6-Cl2-C6H3-CH2C2H5CH3646H2，4-(CH3)2-C6H3-CH2C2H5CH3647H2，5-(CH3)2-C6H3-CH2C2H5CH3648 H3，4-(CH3)2-C6H3-CH2C2H5CH3649 H3，5-(CH3)2-C6H3-CH2C2H5CH3650 H1-萘基-CH2C2H5CH3651 H2-萘基-CH2C2H5CH3652 HC6H5-CH(CH3) C2H5CH3653 H2-Cl-C6H4-CH(CH3) C2H5CH3654 H3-Cl-C6H4-CH(CH3) C2H5CH3655 H4-Cl-C6H4-CH(CH3) C2H5CH3656 H2-CH3-C6H4-CH(CH3) C2H5CH3657 H3-CH3-C6H4-CH(CH3) C2H5CH3658 H4-CH3-C6H4-CH(CH3) C2H5CH3659 H2-CF3-C6H4-CH(CH3) C2H5CH3660 H3-CF3-C6H4-CH(CH3) C2H5CH3661 H4-CF3-C6H4-CH(CH3) C2H5CH3662 H2-t-C4H9-C6H4-CH(CH3) C2H5CH3663 H3-t-C4H9-C6H4-CH(CH3) C2H5CH3664 H4-t-C4H9-C6H4-CH(CH3) C2H5CH3665 H2-CH3O-C6H4-CH(CH3) C2H5CH3666 H3-CH3O-C6H4-CH(CH3) C2H5CH3667 H4-CH3O-C6H4-CH(CH3) C2H5CH3668 H2-氰基-C6H4-CH(CH3)C2H5CH3669 H3-氰基-C6H4-CH(CH3)C2H5CH3670 H4-氰基-C6H4-CH(CH3)C2H5CH3671 H2，4-Cl2-C6H3-CH(CH3) C2H5CH3672 H3，4-Cl2-C6H3-CH(CH3) C2H5CH3673 H3，5-Cl2-C6H3-CH(CH3) C2H5CH3674 H2，4-(CH3)2-C6H3-CH(CH3) C2H5CH3675 H2，5-(CH3)2-C6H3-CH(CH3) C2H5CH3676 HCH3OOC-CH2C2H5CH3677 HC2H5OOC-CH2C2H5CH3678 Hi-C3H7OOC-CH2C2H5CH3679 Ht-C4H9OOC-CH2C2H5CH3680 Ht-C4H9OOC-CH(CH3) C2H5CH3681 HN≡C-CH2C2H5CH3682 HC6H5CO-CH2C2H5CH3683 H吡啶-2-基-甲基 C2H5CH3684 H吡嗪-2-基-甲基 C2H5CH3685 H嘧啶-2-基-甲基 C2H5CH3686 H呋喃-2-基-甲基 C2H5CH3687 H吡咯-2-基-甲基 C2H5CH3688 HN-甲基-吡咯-2-基-甲基 C2H5CH3689 H噻吩-2-基-甲基 C2H5CH3690 H異噁唑-5-基-甲基C2H5CH3691 H噻唑-2-基-甲基 C2H5CH3692 H噻唑-5-基-甲基 C2H5CH3693 H噁唑-2-基-甲基 C2H5CH3694 H吡唑-3-基-甲基 C2H5CH3695H 苯并呋喃-2-基-甲基C2H5CH3696H 吲哚-2-基-甲基C2H5CH3697H 吲哚-3-基-甲基C2H5CH3698H 苯并噻唑-2-基-甲基C2H5CH3699H 喹啉-2-基-甲基C2H5CH3700H 4-Cl-C6H4OCH(CH3)-CH2C2H5CH3701CH3H C2H5CH3702CH3CH3C2H5CH3703CH3t-C4H9C2H5CH3704CH3CH2＝CH-CH2C2H5CH3705CH3CH2＝C(-Cl)-CH2C2H5CH3706CH3CH2＝C(CH3)-CH2C2H5CH3707CH3CH3CH＝CH-CH2C2H5CH3708CH3HC≡CCH2C2H5CH3709CH3CH3C≡C-CH2C2H5CH3710CH3環(huán)-C6H11C2H5CH3711CH3C6H5-CH2C2H5CH3712CH32-F-C6H4-CH2C2H5CH3713CH33-F-C6H4-CH2C2H5CH3714CH34-F-C6H4-CH2C2H5CH3715CH32-Cl-C6H4-CH2C2H5CH3716CH33-Cl-C6H4-CH2C2H5CH3717CH34-Cl-C6H4-CH2C2H5CH3718CH32-Br-C6H4-CH2C2H5CH3719CH33-Br-C6H4-CH2C2H5CH3720CH34-Br-C6H4-CH2C2H5CH3721CH32-CH3-C6H4-CH2C2H5CH3722CH33-CH3-C6H4-CH2C2H5CH3723CH34-CH3-C6H4-CH2C2H5CH3724CH32-CF3-C6H4-CH2C2H5CH3725CH33-CF3-C6H4-CH2C2H5CH3726CH34-CF3-C6H4-CH2C2H5CH3727CH32-i-C3H7-C6H4-CH2C2H5CH3728CH33-i-C3H7-C6H4-CH2C2H5CH3729CH34-i-C3H7-C6H4-CH2C2H5CH3730CH32-t-C4H9-C6H4-CH2C2H5CH3731CH33-t-C4H9-C6H4-CH2C2H5CH3732CH34-t-C4H9-C6H4-CH2C2H5CH3733CH32-CH3O-C6H4-CH2C2H5CH3734CH33-CH3O-C6H4-CH2C2H5CH3735CH34-CH3O-C6H4-CH2C2H5CH3736CH32-氰基-C6H4-CH2C2H5CH3737CH33-氰基-C6H4-CH2C2H5CH3738CH34-氰基-C6H4-CH2C2H5CH3739CH32-硝基-C6H4-CH2C2H5CH3740CH33-硝基-C6H4-CH2C2H5CH3741CH34-硝基-C6H4-CH2C2H5CH3742CH32，4-Cl2-C6H3-CH2C2H5CH3743CH33，4-Cl2-C6H3-CH2C2H5CH3744CH33，5-Cl2-C6H3-CH2C2H5CH3745CH32，6-Cl2-C6H3-CH2C2H5CH3746CH32，4-(CH3)2-C6H3-CH2C2H5CH3747CH32，5-(CH3)2-C6H3-CH2C2H5CH3748CH33，4-(CH3)2-C6H3-CH2C2H5CH3749CH33，5-(CH3)2-C6H3-CH2C2H5CH3750CH31-萘基-CH2C2H5CH3751CH32-萘基-CH2C2H5CH3752CH3C6H5-CH(CH3) C2H5CH3753CH32-Cl-C6H4-CH(CH3) C2H5CH3754CH33-Cl-C6H4-CH(CH3) C2H5CH3755CH34-Cl-C6H4-CH(CH3) C2H5CH3756CH32-CH3-C6H4-CH(CH3) C2H5CH3757CH33-CH3-C6H4-CH(CH3) C2H5CH3758CH34-CH3-C6H4-CH(CH3) C2H5CH3759CH32-CF3-C6H4-CH(CH3) C2H5CH3760CH33-CF3-C6H4-CH(CH3) C2H5CH3761CH34-CF3-C6H4-CH(CH3) C2H5CH3762CH32-t-C4H9-C6H4-CH(CH3) C2H5CH3763CH33-t-C4H9-C6H4-CH(CH3) C2H5CH3764CH34-t-C4H9-C6H4-CH(CH3) C2H5CH3765CH32-CH3O-C6H4-CH(CH3) C2H5CH3766CH33-CH3O-C6H4-CH(CH3) C2H5CH3767CH34-CH3O-C6H4-CH(CH3) C2H5CH3768CH32-氰基-C6H4-CH(CH3)C2H5CH3769CH33-氰基-C6H4-CH(CH3)C2H5CH3770CH34-氰基-C6H4-CH(CH3)C2H5CH3771CH32，4-Cl2-C6H3-CH(CH3) C2H5CH3772CH33，4-Cl2-C6H3-CH(CH3) C2H5CH3773CH33，5-Cl2-C6H3-CH(CH3) C2H5CH3774CH32，4-(CH3)2-C6H3-CH(CH3) C2H5CH3775CH32，5-(CH3)2-C6H3-CH(CH3) C2H5CH3776CH3CH3OOC-CH2C2H5CH3777CH3C2H5OOC-CH2C2H5CH3778CH3i-C3H7OOC-CH2C2H5CH3779CH3t-C4H9OOC-CH2C2H5CH3780CH3t-C4H9OOC-CH(CH3) C2H5CH3781CH3N≡C-CH2C2H5CH3782CH3C6H5CO-CH2C2H5CH3783CH3吡啶-2-基-甲基 C2H5CH3784CH3吡嗪-2-基-甲基 C2H5CH3785CH3嘧啶-2-基-甲基 C2H5CH3786CH3呋喃-2-基-甲基 C2H5CH3787CH3吡咯-2-基-甲基 C2H5CH3788CH3N-甲基-吡咯-2-基-甲基 C2H5CH3789CH3噻吩-2-基-甲基 C2H5CH3790CH3異噁唑-5-基-甲基 C2H5CH3791CH3噻唑-2-基-甲基 C2H5CH3792CH3噻唑-5-基-甲基 C2H5CH3793CH3噁唑-2-基-甲基 C2H5CH3794CH3吡唑-3-基-甲基 C2H5CH3795CH3苯并呋喃-2-基-甲基 C2H5CH3796CH3吲哚-2-基-甲基 C2H5CH3797CH3吲哚-3-基-甲基 C2H5CH3798CH3苯并噻唑-2-基-甲基 C2H5CH3799CH3喹啉-2-基-甲基 C2H5CH3800CH34-Cl-C6H4OCH(CH3)-CH2C2H5CH3
表7 化合物編號(hào)R1R2R61H HH2H CH3H3H t-C4H9H4H CH2＝CH-CH2H5H CH2＝C(-Cl)-CH2H6H CH2＝C(CH3)-CH2H7H CH3CH＝CH-CH2H8H HC≡CH2H9H CH3C≡C-CH2H10 H 環(huán)-C6H11H11 H C6H5-CH2H12 H 2-F-C6H4-CH2H13 H 3-F-C6H4-CH2H14 H 4-F-C6H4-CH2H15 H 2-Cl-C6H4-CH2H16 H 3-Cl-C6H4-CH2H17 H 4-Cl-C6H4-CH2H18 H 2-Br-C6H4-CH2H19 H 3-Br-C6H4-CH2H20 H 4-Br-C6H4-CH2H21 H 2-CH3-C6H4-CH2H22 H 3-CH3-C6H4-CH2H23 H 4-CH3-C6H4-CH2H24 H 2-CF3-C6H4-CH2H25 H 3-CF3-C6H4-CH2H26 H 4-CF3-C6H4-CH2H27 H 2-i-C3H7-C6H4-CH2H28 H 3-i-C3H7-C6H4-CH2H29 H 4-i-C3H7-C6H4-CH2H30 H 2-t-C4H9-C6H4-CH2H31 H 3-t-C4H9-C6H4-CH2H32 H 4-t-C4H9-C6H4-CH2H33 H 2-CH3O-C6H4-CH2H34 H 3-CH3O-C6H4-CH2H35 H 4-CH3O-C6H4-CH2H36H2-氰基-C6H4-CH2H37H3-氰基-C6H4-CH2H38H4-氰基-C6H4-CH2H39H2-硝基-C6H4-CH2H40H3-硝基-C6H4-CH2H41H4-硝基-C6H4-CH2H42H2，4-Cl2-C6H3-CH2H43H3，4-Cl2-C6H3-CH2H44H3，5-Cl2-C6H3-CH2H45H2，6-Cl2-C6H3-CH2H46H2，4-(CH3)2-C6H3-CH2H47H2，5-(CH3)2-C6H3-CH2H48H3，4-(CH3)2-C6H3-CH2H49H3，5-(CH3)2-C6H3-CH2H50H1-萘基-CH2H51H2-萘基-CH2H52HC6H5-CH(CH3)H53H2-Cl-C6H4-CH(CH3) H54H3-Cl-C6H4-CH(CH3) H55H4-Cl-C6H4-CH(CH3) H56H2-CH3-C6H4-CH(CH3) H57H3-CH3-C6H4-CH(CH3) H58H4-CH3-C6H4-CH(CH3) H59H2-CF3-C6H4-CH(CH3) H60H3-CF3-C6H4-CH(CH3) H61H4-CF3-C6H4-CH(CH3) H62H2-t-C4H9-C6H4-CH(CH3) H63H3-t-C4H9-C6H4-CH(CH3) H64H4-t-C4H9-C6H4-CH(CH3) H65H2-CH3O-C6H4-CH(CH3)H66H3-CH3O-C6H4-CH(CH3)H67H4-CH3O-C6H4-CH(CH3)H68H2-氰基-C6H4-CH(CH3) H69H3-氰基-C6H4-CH(CH3) H70H4-氰基-C6H4-CH(CH3) H71H2，4-Cl2-C6H3-CH(CH3) H72H3，5-Cl2-C6H3-CH(CH3) H73H3，5-Cl2-C6H3-CH(CH3) H74H2，4-(CH3)2-C6H3-CH(CH3) H75H2，5-(CH3)2-C6H3-CH(CH3) H76HCH3OOC-CH2H77HC2H5OOC-CH2H78Hi-C3H7OOC-CH2H79Ht-C4H9OOC-CH2H80Ht-C4H9OOC-CH(CH3) H81HN≡C-CH2H82HC6H5CO-CH2H83H 吡啶-2-基-甲基 H84H 吡嗪-2-基-甲基 H85H 嘧啶-2-基-甲基 H86H 呋喃-2-基-甲基 H87H 吡咯-2-基-甲基 H88H N-甲基-吡咯-2-基-甲基H89H 噻吩-2-基-甲基 H90H 異噁唑-5-基-甲基 H91H 噻唑-2-基-甲基 H92H 噻唑-5-基-甲基 H93H 噁唑-2-基-甲基 H94H 吡唑-3-基-甲基 H95H 苯并呋喃-2-基-甲基 H96H 吲哚-2-基-甲基 H97H 吲哚-3-基-甲基 H98H 苯并噻唑-2-基-甲基 H99H 喹啉-2-基-甲基 H100 H 4-Cl-C6H4OCH(CH3)-CH2H101 CH3HH102 CH3CH3H103 CH3t-C4H9H104 CH3CH2＝CH-CH2H105 CH3CH2＝C(-Cl)-CH2H106 CH3C(CH3)-CH2H107 CH3CH3CH＝CH-CH2H108 CH3HC≡CCH2H109 CH3CH3C≡C-CH2H110 CH3環(huán)-C6H11H111 CH3C6H5-CH2H112 CH32-F-C6H4-CH2H113 CH33-F-C6H4-CH2H114 CH34-F-C6H4-CH2H115 CH32-Cl-C6H4-CH2H116 CH33-Cl-C6H4-CH2H117 CH34-Cl-C6H4-CH2H118 CH32-Br-C6H4-CH2H119 CH33-Br-C6H4-CH2H120 CH34-Br-C6H4-CH2H121 CH32-CH3-C6H4-CH2H122 CH33-CH3-C6H4-CH2H123 CH34-CH3-C6H4-CH2H124 CH32-CF3-C6H4-CH2H125 CH33-CF3-C6H4-CH2H126 CH34-CF3-C6H4-CH2H127 CH32-i-C3H7-C6H4-CH2H128 CH33-i-C3H7-C6H4-CH2H129 CH34-i-C3H7-C6H4-CH2H130CH32-t-C4H9-C6H4-CH2H131CH33-t-C4H9-C6H4-CH2H132CH34-t-C4H9-C6H4-CH2H133CH32-CH3O-C6H4-CH2H134CH33-CH3O-C6H4-CH2H135CH34-CH3O-C6H4-CH2H136CH32-氰基-C6H4-CH2H137CH33-氰基-C6H4-CH2H138CH34-氰基-C6H4-CH2H139CH32-硝基-C6H4-CH2H140CH33-硝基-C6H4-CH2H141CH34-硝基-C6H4-CH2H142CH32，4-Cl2-C6H3-CH2H143CH33，4-Cl2-C6H3-CH2H144CH33，5-Cl2-C6H3-CH2H145CH32，6-Cl2-C6H3-CH2H146CH32，4-(CH3)2-C6H3-CH2H147CH32，5-(CH3)2-C6H3-CH2H148CH33，4-(CH3)2-C6H3-CH2H149CH33，5-(CH3)2-C6H3-CH2H150CH31-萘基-CH2H151CH32-萘基-CH2H152CH3C6H5-CH(CH3) H153CH32-Cl-C6H4-CH(CH3) H154CH33-Cl-C6H4-CH(CH3) H155CH34-Cl-C6H4-CH(CH3) H156CH3CH3-C6H4-CH(CH3) H157CH33-CH3-C6H4-CH(CH3)H158CH34-CH3-C6H4-CH(CH3)H159CH32-CF3-C6H4-CH(CH3)H160CH33-CF3-C6H4-CH(CH3)H161CH34-CF3-C6H4-CH(CH3)H162CH32-t-C4H9-C6H4-CH(CH3)H163CH33-t-C4H9-C6H4-CH(CH3)H164CH34-t-C4H9-C6H4-CH(CH3)H165CH32-CH3O-C6H4-CH(CH3) H166CH33-CH3O-C6H4-CH(CH3) H167CH34-CH3O-C6H4-CH(CH3) H168CH32-氰基-C6H4-CH(CH3)H169CH33-氰基-C6H4-CH(CH3)H170CH34-氰基-C6H4-CH(CH3)H171CH32，4-Cl2-C6H3-CH(CH3) H172CH33，4-Cl2-C6H3-CH(CH3) H173CH33，5-Cl2-C6H3-CH(CH3) H174CH32，4-(CH3)2-C6H3-CH(CH3) H175CH32，5-(CH3)2-C6H3-CH(CH3) H176CH3CH3OOC-CH2H177CH3C2H5OOC-CH2H178CH3i-C3H7OOC-CH2H179CH3t-C4H9OOC-CH2H180CH3t-C4H9OOC-CH(CH3)H181CH3N≡C-CH2H182CH3C6H5CO-CH2H183CH3吡啶-2-基-甲基 H184CH3吡嗪-2-基-甲基 H185CH3嘧啶-2-基-甲基 H186CH3呋喃-2-基-甲基 H187CH3吡咯-2-基-甲基 H188CH3N-甲基-吡咯-2-基-甲基H189CH3噻吩-2-基-甲基 H190CH3異噁唑-5-基-甲基 H191CH3噻唑-2-基-甲基 H192CH3噻唑-5-基-甲基 H193CH3噁唑-2-基-甲基 H194CH3吡唑-3-基-甲基 H195CH3苯并呋喃-2-基-甲基 H196CH3吲哚-2-基-甲基 H197CH3吲哚-3-基-甲基 H198CH3苯并噻唑-2-基-甲基 H199CH3喹啉-2-基-甲基 H200CH34-Cl-C6H4OCH(CH3)-CH2H201H H CH3202H CH3CH3203H t-C4H9CH3204H CH2＝CH-CH2CH3205H CH2＝C(-Cl)-CH2CH3206H CH2＝C(CH3)-CH2CH3207H CH3CH＝CH-CH2CH3208H HC≡CCH2CH3209H CH3C≡C-CH2CH3210H 環(huán)-C6H11CH3211H C6H5-CH2CH3212H 2-F-C6H4-CH2CH3213H 3-F-C6H4-CH2CH3214H 4-F-C6H4-CH2CH3215H 2-Cl-C6H4-CH2CH3216H 3-Cl-C6H4-CH2CH3217H 4-Cl-C6H4-CH2CH3218H 2-Br-C6H4-CH2CH3219H 3-Br-C6H4-CH2CH3220H 4-Br-C6H4-CH2CH3221H 2-CH3-C6H4-CH2CH3222H 3-CH3-C6H4-CH2CH3223H 4-CH3-C6H4-CH2CH3224H2-CF3-C6H4-CH2CH3225H3-CF3-C6H4-CH2CH3226H4-CF3-C6H4-CH2CH3227H2-i-C3H7-C6H4-CH2CH3228H3-i-C3H7-C6H4-CH2CH3229H4-i-C3H7-C6H4-CH2CH3230H2-t-C4H9-C6H4-CH2CH3231H3-t-C4H9-C6H4-CH2CH3232H4-t-C4H9-C6H4-CH2CH3233H2-CH3O-C6H4-CH2CH3234H3-CH3O-C6H4-CH2CH3235H4-CH3O-C6H4-CH2CH3236H2-氰基-C6H4-CH2CH3237H3-氰基-C6H4-CH2CH3238H4-氰基-C6H4-CH2CH3239H2-硝基-C6H4-CH2CH3240H3-硝基-C6H4-CH2CH3241H4-硝基-C6H4-CH2CH3242H2，4-Cl2-C6H3-CH2CH3243H3，4-Cl2-C6H3-CH2CH3244H3，5-Cl2-C6H3-CH2CH3245H2，6-Cl2-C6H3-CH2CH3246H2，4-(CH3)2-C6H3-CH2CH3247H2，5-(CH3)2-C6H3-CH2CH3248H3，4-(CH3)2-C6H3-CH2CH3249H3，5-(CH3)2-C6H3-CH2CH3250H1-萘基-CH2CH3251H2-萘基-CH2CH3252HC6H5-CH(CH3)CH3253H2-Cl-C6H4-CH(CH3) CH3254H3-Cl-C6H4-CH(CH3) CH3255H4-Cl-C6H4-CH(CH3) CH3256H2-CH3-C6H4-CH(CH3) CH3257H3-CH3-C6H4-CH(CH3) CH3258H4-CH3-C6H4-CH(CH3) CH3259H2-CF3-C6H4-CH(CH3) CH3260H3-CF3-C6H4-CH(CH3) CH3261H4-CF3-C6H4-CH(CH3) CH3262H2-t-C4H9-C6H4-CH(CH3) CH3263H3-t-C4H9-C6H4-CH(CH3) CH3264H4-t-C4H9-C6H4-CH(CH3) CH3265H2-CH3O-C6H4-CH(CH3)CH3266H3-CH3O-C6H4-CH(CH3)CH3267H4-CH3O-C6H4-CH(CH3)CH3268H2-氰基-C6H4-CH(CH3) CH3269H3-氰基-C6H4-CH(CH3) CH3270H4-氰基-C6H4-CH(CH3) CH3271H 2，4-Cl2-C6H3-CH(CH3) CH3272H 3，4-Cl2-C6H3-CH(CH3) CH3273H 3，5-Cl2-C6H3-CH(CH3) CH3274H 2，4-(CH3)2-C6H3-CH(CH3) CH3275H 2，5-(CH3)2-C6H3-CH(CH3) CH3276H CH3OOC-CH2CH3277H C2H5OOC-CH2CH3278H i-C3H7OOC-CH2CH3279H t-C4H9OOC-CH2CH3280H t-C4H9OOC-CH(CH3) CH3281H N≡C-CH2CH3282H C6H5CO-CH2CH3283H 吡啶-2-基-甲基 CH3284H 吡嗪-2-基-甲基 CH3285H 嘧啶-2-基-甲基 CH3286H 呋喃-2-基-甲基 CH3287H 吡咯-2-基-甲基 CH3288H N-甲基-吡咯-2-基-甲基 CH3289H 噻吩-2-基-甲基 CH3290H 異噁唑-5-基-甲基CH3291H 噻唑-2-基-甲基 CH3292H 噻唑-5-基-甲基 CH3293H 噁唑-2-基-甲基 CH3294H 吡唑-3-基-甲基 CH3295H 苯并呋喃-2-基-甲基 CH3296H 吲哚-2-基-甲基 CH3297H 吲哚-3-基-甲基 CH3298H 苯并噻唑-2-基-甲基 CH3299H 喹啉-2-基-甲基 CH3300H 4-Cl-C6H4OCH(CH3)-CH2CH3301CH3H CH3302CH3CH3CH3303CH3t-C4H9CH3304CH3CH2＝CH-CH2CH3305CH3CH2＝C(-Cl)-CH2CH3306CH3CH2＝C(CH3)-CH2CH3307CH3CH3CH＝CH-CH2CH3308CH3HC≡sCCH2CH3309CH3CH3C≡C-CH2CH3310CH3環(huán)-C6H11CH33311CH3C6H5-CH2CH3332CH32-F-C6H4-CH2CH3313CH33-F-C6H4-CH2CH3314CH34-F-C6H4-CH2CH3315CH32-Cl-C6H4-CH2CH3316CH33-Cl-C6H4-CH2CH3317CH34-Cl-C6H4-CH2CH3318CH32-Br-C6H4-CH2CH3319CH33-Br-C6H4-CH2CH3320CH34-Br-C6H4-CH2CH3321CH32-CH3-C6H4-CH2CH3322CH33-CH3-C6H4-CH2CH3323CH34-CH3-C6H4-CH2CH3324CH32-CF3-C6H4-CH2CH3325CH33-CF3-C6H4-CH2CH3326CH34-CF3-C6H4-CH2CH3327CH32-i-C3H7-C6H4-CH2CH3328CH33-i-C3H7-C6H4-CH2CH3329CH34-i-C3H7-C6H4-CH2CH3330CH32-t-C4H9-C6H4-CH2CH3331CH33-t-C4H9-C6H4-CH2CH3332CH34-t-C4H9-C6H4-CH2CH3333CH32-CH3O-C6H4-CH2CH3334CH33-CH3O-C6H4-CH2CH3335CH34-CH3O-C6H4-CH2CH3336CH32-氰基-C6H4-CH2CH3337CH33-氰基-C6H4-CH2CH3338CH34-氰基-C6H4-CH2CH3339CH32-硝基-C6H4-CH2CH3340CH33-硝基-C6H4-CH2CH3341CH34-硝基-C6H4-CH2CH3342CH32，4-Cl2-C6H3-CH2CH3343CH33，4-Cl2-C6H3-CH2CH3344CH33，5-Cl2-C6H3-CH2CH3345CH32，6-Cl2-C6H3-CH2CH3346CH32，4-(CH3)2-C6H3-CH2CH3347CH32，5-(CH3)2-C6H3-CH2CH3348CH33，4-(CH3)2-C6H3-CH2CH3349CH33，5-(CH3)2-C6H3-CH2CH3350CH31-萘基-CH2CH3351CH32-萘基-CH2CH3352CH3C6H5-CH(CH3) CH3353CH32-Cl-C6H4-CH(CH3) CH3354CH33-Cl-C6H4-CH(CH3) CH3355CH34-Cl-C6H4-CH(CH3) CH3356CH32-CH3-C6H4-CH(CH3)CH3357CH33-CH3-C6H4-CH(CH3)CH3358CH34-CH3-C6H4-CH(CH3)CH3359CH32-CF3-C6H4-CH(CH3)CH3360CH33-CF3-C6H4-CH(CH3)CH3361CH34-CF3-C6H4-CH(CH3)CH3362CH32-t-C4H9-C6H4-CH(CH3)CH3363CH33-t-C4H9-C6H4-CH(CH3)CH3364CH34-t-C4H9-C6H4-CH(CH3)CH3365CH32-CH3O-C6H4-CH(CH3)CH3366CH33-CH3O-C6H4-CH(CH3)CH3367CH34-CH3O-C6H4-CH(CH3)CH3368CH32-氰基-C6H4-CH(CH3) CH3369CH33-氰基-C6H4-CH(CH3) CH3370CH34-氰基-C6H4-CH(CH3) CH3371CH32，4-Cl2-C6H3-CH(CH3) CH3372CH33，4-Cl2-C6H3-CH(CH3) CH3373CH33，5-Cl2-C6H3-CH(CH3) CH3374CH32，4-(CH3)2-C6H3-CH(CH3) CH3375CH32，5-(CH3)2-C6H3-CH(CH3) CH3376CH3CH3OOC-CH2CH3377CH3C2H5OOC-CH2CH3378CH3i-C3H7OOC-CH2CH3379CH3t-C4H9OOC-CH2CH3380CH3t-C4H9OOC-CH(CH3)CH3381CH3N≡C-CH2CH3382CH3C6H5CO-CH2CH3383CH3吡啶-2-基-甲基 CH3384CH3吡嗪-2-基-甲基 CH3385CH3嘧啶-2-基-甲基 CH3386CH3呋喃-2-基-甲基 CH3387CH3吡咯-2-基-甲基 CH3388CH3N-甲基-吡咯-2-基-甲基CH3389CH3噻吩-2-基-甲基 CH3390CH3異噁唑-5-基-甲基 CH3391CH3噻唑-2-基-甲基 CH3392CH3噻唑-5-基-甲基 CH3393CH3噁唑-2-基-甲基 CH3394CH3吡唑-3-基-甲基 CH3395CH3苯并呋喃-2-基-甲基 CH3336CH3吲哚-2-基-甲基 CH3397CH3吲哚-3-基-甲基 CH3398CH3苯并噻唑-2-基-甲基 CH3399CH3喹啉-2-基-甲基 CH3400CH34-Cl-C6H4OCH(CH3)-CH2CH3
本發(fā)明的式I所示新穎化合物適于用作殺真菌劑。
本發(fā)明新穎化合物或含有它們的組合物例如可以下述劑型應(yīng)用可直接噴灑的溶液，顆粒，懸浮液(包括高濃度的水性、油性或其它懸浮液)，分散劑，乳劑，油性分散劑，糊劑，粉劑，撒播劑或顆粒劑，用噴灑、霧化、噴粉、播撒或澆灌來使用。根據(jù)使用的目的指導(dǎo)應(yīng)用的劑型；但無論哪種情況都要盡可能地將本發(fā)明活性成分分散開使用。
通常是將活性化合物噴灑或噴粉到植物上或用活性化合物處理植物的種子。
各種制劑按照已知方法制備，例如用溶劑和/或載體稀釋，如需要，還可使用乳化劑和分散劑，在用水作為稀釋劑時(shí)、也可用其它有機(jī)溶劑作為助溶劑。助溶劑主要可考慮用芳烴溶劑(例如二甲苯)，氯代芳烴(如氯苯)，脂烴(如石油餾份)，醇類(如甲醇、丁醇)，酮類(如環(huán)己酮)，胺類(如乙醇胺、二甲基甲酰胺)和水；載體如天然礦石粉(如高嶺土，粘土，滑石粉，白堊粉)和合成的無機(jī)物粉(如高度分散的硅酸、硅酸鹽)；乳化劑如非離子型和陰離子型乳化劑(例如聚氧乙烯—脂肪醇醚，烷基磺酸鹽和芳基磺酸鹽)；分散劑如木質(zhì)素—亞硫酸廢液和甲基纖維素。
表面活性劑可考慮用芳香磺酸例如木質(zhì)素—、酚—、萘—、和二丁基萘—磺酸的堿金屬鹽、堿土金屬鹽、銨鹽，以及脂肪酸鹽，烷基—和烷芳基磺酸鹽，烷基—、十二烷醚基—和脂肪醇基—硫酸鹽，以及十六、十七和十八醇的硫酸單酯鹽，脂肪醇乙二醇醚的鹽，磺酸化萘及其衍生物與甲醛的縮合產(chǎn)物，萘或萘磺酸與苯酚和甲醛的縮合產(chǎn)物，聚氧乙烯辛基酚醚，乙氧基化的異辛基—、辛基或壬基酚，烷基酚—聚二醇醚或三丁苯基聚乙二醇醚，烷芳基聚醚醇，異十三碳醇，脂醇—環(huán)氧乙烷縮合物，乙氧基化的蓖麻油，聚氧乙烯烷基醚，聚氧丙烯，十二烷醇聚二醇醚乙酸酯，山梨醇酯，木質(zhì)素—亞硫酸廢液或甲基纖維素。
顆粒、粉劑和撒播劑的制備方法是將活性成分與固體載體混合或共同研磨。
顆粒劑，例如覆蓋型顆粒、浸漬型顆粒和均勻型顆粒劑可將活性成分與固體載體結(jié)合而制備。固體載體物質(zhì)是礦土如硅膠、硅酸、硅膠、硅酸鹽、滑石、高嶺土、石灰石、石灰、白堊土、紅玄武土、黃土、陶土、白云石、硅藻土、硫酸鈣和鎂、氧化鎂、磨細(xì)的塑料和肥料如硫酸銨、磷酸銨、硝酸銨和脲，植物制品，如谷粉、樹皮粉、木材粉和堅(jiān)果殼粉、纖維素粉，或其它固體載體。
這些制劑的示例為I.90重量份表1中的化合物2(即1/2)和10重量份N—甲基—α—吡咯烷酮的溶液，它適于以很細(xì)的液滴的形式使用；II.20重量份表1中的化合物36(即1/36)、80重量份二甲苯、10重量份8—10摩爾環(huán)氧乙烷加合到1摩爾N—羥乙基油酰胺上的產(chǎn)物、5重量份十二烷基苯磺酸鈣、5重量份40摩爾環(huán)氧乙烷加合到1摩爾蓖麻油上的產(chǎn)物的混合物，將該溶液精細(xì)分散到水中得到一分散體；III.20重量份化合物1/49、40重量份環(huán)己酮、30重量份異丁醇和20重量份40摩爾環(huán)氧乙烷加合到1摩爾蓖麻油上的產(chǎn)物的水分散體；IV.20重量份化合物1/58、25重量份環(huán)己醇、65重量份沸程為210—280℃的礦物油級(jí)分和10重量份40摩爾環(huán)氧乙烷加合到1摩爾蓖麻油上的產(chǎn)物的水分散體；V.80重量份化合物1/2、3重量份二異丁基萘—α—磺酸鈉、10重量份得自亞硫酸廢液的木質(zhì)素磺酸的鈉鹽和7重量份硅膠顆粒的混合物在錘磨機(jī)中研磨，將該混合物精細(xì)分散于水中，得到噴灑用液；VI.3重量份化合物1/36和97重量份細(xì)粉高嶺土的緊密摻合物，該撒粉組合物含有3％wt活性化合物；VII.30重量份化合物1/49、92重量份硅膠顆粒和8重量份噴灑到硅膠顆粒表面上的石蠟油的緊密摻合物，該制劑使活性化合物能很好地粘附；VIII.40重量份化合物1/58、10重量份酚磺酸鈉—脲—甲醛縮聚物、2重量份硅膠和48重量份水的穩(wěn)定水分散體，它可以進(jìn)一步稀釋；IX.20重量份化合物1/20、2重量份十二烷基苯磺酸鈣、8重量份脂肪醇—聚二醇醚、20重量份酚磺酸鈉—脲—甲醛縮合物和68重量份直鏈礦物油的穩(wěn)定油分散體。
本發(fā)明新穎化合物對(duì)植物病理性真菌有優(yōu)異和廣譜的作用，尤其是對(duì)于囊菌屬和擔(dān)子菌屬。它們部分可系統(tǒng)地起作用，并可用作葉片和土壤中的殺真菌劑。
它們對(duì)各種濃作物及其種子上的多種真菌的殺滅作用特別有意義，特別是對(duì)小麥、黑麥、大麥、燕麥、水稻、玉米、草、棉花、大豆、咖啡、甘蔗、葡萄、水果植物、觀賞植物和蔬菜如黃瓜、豆角、南瓜類植物。
使用本化合物時(shí)是用對(duì)真菌有效量的化合物處理被保護(hù)的種子、植物、物料或土壤，使其免受真菌的侵害。
這些化合物可在物料、植物或種子被真菌感染前或感染后使用。
本發(fā)明新穎化合物特別適于防治如下的植物病害糧食中的麥類白粉菌，南瓜類值物中的瓜類白粉菌和黃瓜白粉病球殼霉，蘋果中的白絲足球霉，葡萄中的葡萄白粉病鉤絲殼霉，糧食作物中的雙孢銹菌屬，棉花和草中的絲核菌屬，糧食作物和甘蔗中的黑粉菌屬，蘋果的蘋果黑星病菌，糧食作物的長蠕孢屬，小麥的穎斑枯病殼針孢霉，草莓和葡萄的灰緣葡萄孢，花生的褐斑病菌，小麥和大麥的假小白尾孢，水稻的Pyricularia oryzae，馬鈴薯和番茄的疫霉，各種植物的鐮刀霉屬和輪枝孢菌屬，葡萄的霜霉菌，蔬菜和水果的交鏈孢霉。
該新的化合物也可用于材料防護(hù)(木材防護(hù))，例如防治擬青霉。
該殺真菌劑組合物通常含活性化合物0.1—95％(重量％)，優(yōu)選為0.5～90％(重量％)。
本發(fā)明的化合物用量根據(jù)所需達(dá)到的效果每公頃用0.02～3kg活性化合物。
用于種子處理的用量為每公斤種子用活性化合物0.001～50g，優(yōu)選為0.01～10g。
用作殺真菌劑的本發(fā)明化合物還可與其它活性化合物一起使用，例如與除草劑、殺蟲劑、生長調(diào)節(jié)劑、殺真菌劑或化肥一起使用。
與殺真菌劑混合時(shí)，在很多情況下可以拓寬殺真菌活性的譜。
下列殺真菌劑可與本發(fā)明化合物一起組合使用(應(yīng)注意這只是舉例說明，并非窮舉)硫，二硫代氨基甲酸鹽及它們的衍生物，如二甲基二硫代氨基甲酸亞鐵、二甲基二硫代氨基甲酸鋅、亞乙基雙二硫代氨基甲酸鋅、亞乙基雙二硫代氨基甲酸錳、亞乙基雙二硫代氨基甲酸錳鋅、二硫化四甲基秋蘭姆、N，N’—亞乙基雙二硫代氨基甲酸鋅的氨配合物、N，N’—亞丙基雙二硫代氨基甲酸鋅的氨配合物、N，N’—多亞丙基雙(硫代氨基甲?；?二硫化物，硝基衍生物，如巴豆酸二硝基(1—甲基庚基)苯酯、3，3—二甲基丙烯酸2—仲丁基—4，6—二硝基苯酯、異丙基碳酸2—仲丁基—4，6—二硝基苯酯、5—硝基間苯二甲酸二異丙酯，雜環(huán)化合物，如2—十七烷基—2—咪唑啉乙酸酯、2，4—二氯—6—(鄰氯苯氨基)—S—三嗪、苯二甲酰亞氨基硫代膦酸二乙酯、5—氨基—1—β—雙(二甲基氨基)氧膦基—3—苯基—1，2，4—三唑、2，3—二氰基—1，4—二硫代蒽醌、2—硫代—1，3—二硫代環(huán)戊二烯基β4，5—b’喹喔啉、1—(丁基氨基甲酰基)—2—苯并咪唑氨基甲酸甲酯、2—甲氧羰基氨基苯并咪唑、2—(2—呋喃基)苯并咪唑、2—(4—噻唑基)苯并咪唑、N—(1，1，2，2—四氯乙硫基)四氫苯二甲酰亞胺、N—三氯甲硫基四氫苯二甲酰亞胺、N—三氯甲硫基苯二甲酰亞胺，N—二氯一氟甲硫基—N’，N’—二甲基—N—苯基硫酸二酰胺，5—乙氧基—3—三氯甲基—1，2，3—噻二唑，2—硫氰基甲硫基苯并噻唑，1，4—二氯—2，5—二甲氧基苯，4—(2—氯苯基亞肼基)—3—甲基—5—異惡唑酮，吡啶—2—硫代—1—氧化物，8—羥基喹啉或其酮鹽，2，3—二氫—5—羧酰苯胺基—6—甲基—1，4—氧硫雜環(huán)己二烯，2，3—二氫—5—羧酰苯胺基—6—甲基—1，4—氧硫雜環(huán)己二烯—4，4—二氧化物，2—甲基—5，6—二氫—4H—吡喃—3—羧酰苯胺，2—甲基呋喃—3—羧酰苯胺，2，5—二甲基呋喃—3—羧酰苯胺，2，4，5—三甲基呋喃—3—羧酰苯胺，N—環(huán)己基—2，5—二甲基呋喃—3—羧酰胺，N—環(huán)己基—N—甲氧基—2，5—二甲基呋喃—3—羧酰胺，2—甲基苯甲酰苯胺，
2—磺苯甲酰苯胺，N—甲酰基—N—嗎啉—2，2，2—三氯乙基縮醛，哌嗪—1，4—二基雙[1—(2，2，2—三氯乙基)甲酰胺]1—(3，4—二氯苯氨基)—1—甲酰氨基—2，2，2—三氯乙烷，2，6—二甲基—N—十三烷基嗎啉或其鹽，2，6—二甲基—N—環(huán)十二烷基嗎啉或其鹽，N—(3—對(duì)叔丁基苯基—2—甲基—丙基)—順—2，6—二甲基嗎啉，N—(3—對(duì)叔丁基苯基—2—甲基—丙基)—哌啶，1—[2—(2，4—二氯苯基)—4—乙基—1，3—二氧戊環(huán)—2—基乙基]—1H—1，2，4—三唑，1—[2—(2，4—二氯苯基)—4—正丙基—1，3—二氧戊環(huán)—2—基乙基]—1H—1，2，4—三唑，N—正丙基—N—(2，4，6—三氯苯氧基乙基)—N’—咪唑基脲，1—(4—氯苯氧基)—3，3—二甲基—1—(1H—1，2，4—三唑—1—基)—2—丁酮，α—(2—氯苯基)—α—(4—氯苯基)—5—嘧啶甲醇，5—丁基—2—二甲基氨基—4—羥基—6—甲基嘧啶，雙(對(duì)氯苯基)—3—吡啶甲醇，1，2—雙(3—乙氧羰基—2—硫脲基)苯，1，2—雙(3—甲氧羰基—2—硫脲基)苯，以及各種殺真菌劑，如乙酸十二烷基胍，
3—[3—(3，5—二甲基—2—氧基環(huán)己基)—2—羥乙基)]戊二酰亞胺，六氯苯，DL—甲基—N—(2，6—二甲基苯基)—N—2—糠?；谋彼狨?，DL—N—(2，6—二甲基苯基)—N—(2’—甲氧基乙?；?丙氨酸甲酯，N—(2，6—二甲基苯基)—N—氯乙酰基—D，L—2—氨基丁內(nèi)酯，DL—N—(2，6—二甲基苯基)—N—苯乙?；彼峒柞?，5—甲基—5—乙烯基—3—(3，5—二氯苯基)—2，4—二氧代—1，3—噁唑烷，3—[3，5—二氯苯基(—5—甲基—5—甲氧甲基]—1，3—噁唑烷—2，4—二酮，3—(3，5—二氯苯基)—1—異丙基甲氨?；Ｒ颍琋—(3，5—二氯苯基)—1，2—二甲基環(huán)丙烷—1，2—二羧酰胺，2—氰基—(N—乙基氨基甲酰基—2—甲氧亞氨基]乙酰胺，1—[2—(2，4—二氯苯基)戊基]—1H—1，2，4—三唑，2，4—二氟—α—(1H—1，2，4—三唑基甲基)二苯甲基醇，N—(3—氯—2，6—二硝基—4—三氟甲基苯基)—5—三氟甲基—3—氯—2—氨基吡啶，1—[(雙(4—氟苯基)甲基甲硅烷基)甲基]—1H—1，2，4—三唑。
應(yīng)用實(shí)施例2—(甲氧亞氨基—O—[(3—三氟甲基苯基)甲基]苯基乙醛酸甲酯O—甲基肟(A)和2—(甲氧亞氨基—O—[(3—溴苯基)甲基]苯基乙醛酸甲酯0—甲基肟(B)[兩者均在EP 499 823中公開]用作對(duì)比活性化合物。
應(yīng)用實(shí)施例1防治葡萄生單軸霉的活性用含有80％活性化合物和20％乳化劑(以干重計(jì))的水噴灑液噴到盆栽葡萄(變種Muller Thurgau)的葉子上。為了評(píng)價(jià)活性化合物作用的有效期。在噴液干燥后，使這些植物在溫室中呆8天。然后用葡萄生單軸霉的游動(dòng)孢子懸浮液感染這些葉子。然后，先使這些葡萄在水蒸汽飽和的24℃的室中呆48小時(shí)，隨后在20℃—30℃的溫室中呆5天。然后再讓這些植物在上述潮濕室中呆16小時(shí)，然后評(píng)價(jià)葉子底部發(fā)生病害的程度。
在這個(gè)試驗(yàn)中，含16ppm化合物(表/編號(hào))1/32、1/34、1/49、1/58、1/114、1/128、1/134、1/145和1/155的配方處理過的葉子只有15％或更少發(fā)生病害，而未處理的植物有高達(dá)70％發(fā)生病害。含16ppm已知活性化合物A和B的配方處理的植物有高達(dá)35％的發(fā)生病害。
應(yīng)用實(shí)施例2防治大麥網(wǎng)斑病菌的活性用含有80％活性化合物和20％乳化劑(以干重計(jì))的水懸浮液噴灑兩葉期的大麥幼苗(變種Igri)，直至滴濕。24小時(shí)后，用大麥網(wǎng)斑病菌的孢子懸浮液感染這些植物，并在18℃、高濕度室中放置48小時(shí)。然后將這些植物在相對(duì)濕度為70％的20℃—22℃的溫室中再培養(yǎng)5天。然后評(píng)價(jià)葉片發(fā)生病害的程度。
結(jié)果表明，用作含63ppm或16ppm活性化合物的噴哂液時(shí)與已知的對(duì)比活性合物A和B(50％葉子發(fā)生病害)相比，活性化合物(表/編號(hào))1/49和1/58(5％或15％葉子發(fā)生病害)表現(xiàn)出更好的殺真菌活性。
應(yīng)用實(shí)施例3防治小麥上的大刀鐮孢的活性用含有80％活性化合物和20％乳化劑(以干重計(jì))的含水噴液噴灑盆栽小麥(變種Kanzler)的初生葉。第二天，用大刀鐮孢的孢子懸浮液接種這些植物，然后在高溫度(＞90％)的培養(yǎng)室(22—24℃)中培養(yǎng)。6天后，肉眼觀察評(píng)價(jià)病害癥狀的發(fā)展情況。
在這個(gè)試驗(yàn)中，用含500ppm化合物(表/編號(hào))1/8、1/23、1/28、1/29、1/32、1/34、1/35、1/36、1/37、1/58、1/71、1/83、1/114和1/128的制劑處理過的植物有15％或更少發(fā)生病害，未處理的植物高達(dá)80％發(fā)生病害。用含500ppm已知活性化合物A和B的制劑處理的植物分別有80％或60％發(fā)生病害。
權(quán)利要求
1.式I所示的化合物 式中取代基的意義如下Y是氧原子或基團(tuán)NR6；Z1和Z2相互獨(dú)立地為氫原子、鹵原子、烷基、鏈烯基、鏈炔基、烷氧基、鏈烯基氧基、鹵代烷基、鹵代烷氧基、鹵代鏈烯基氧基、氰基或硝基；R1是氫原子、烷基、鹵代烷基或芳基；R2是氫原子，或者未取代或取代的烷基、鏈烯基、鏈炔基、環(huán)烷基、雜芳基烷基、雜環(huán)基、環(huán)烯基、芳烷基、芳基、雜芳基、芳基鏈烯基、雜芳基鏈烯基、芳氧基烷基、雜芳氧基烷基、酰基、芳基羰基、雜芳基羰基或烷氧羰基；R3、R4、R5和R6相互獨(dú)立地為氫原子或烷基；或者R6和R2同與它們相連的氮原子一起形成環(huán)。
2.含有惰性載體和殺真菌活性量的權(quán)利要求1式1化合物的殺真菌劑。
3.一種防治真菌病害的方法，它包括用殺真菌活性量權(quán)利要求1的式I化合物處理真菌或被真菌侵害的材料、植物、種子或土壤。
4.權(quán)利要求1的式I化合物的制備方法，它包括使式II所示酯(式中的R7為烷基) 與式III所示胺或氨反應(yīng)
5.式中的R5為氫原子的權(quán)利要求1的式I化合物的制備方法，它包括使式VI所示醛縮一胺與式VII所示羰基化合物的混合物 與式VIII所示羥胺或肼衍生物(Y為O，NR6)或它們的一種酸加合鹽反應(yīng)R2—Y—NH2(VIII)
6.權(quán)利要求9中的式VI化合物。
7.權(quán)利要求5中的式VI化合物的制備方法，它包括使式IV所示的酯(R7為烷基) 與式V所示伯胺反應(yīng) H2N-R4(V)
8.權(quán)利要求5的式VI化合物—式中的R1為H—的制備方法，它包括將式X所示單烷基(α—烷氧亞氨基苯乙酰胺—式中的R3為烷基 轉(zhuǎn)化成含有兩個(gè)金屬基的金屬化產(chǎn)品，并使該金屬化產(chǎn)品與式XII所示羧酸衍生物反應(yīng) (X＝Cl、OCOR7或OR7，R7為烷基或芳基)。
9.權(quán)利要求5中的式VI所示化合物的制備方法，它包括將權(quán)利要求7中的式X所示單烷基α—烷氧亞氨基苯乙酰胺(式中R3為烷基)轉(zhuǎn)化成含有兩個(gè)金屬基的金屬化產(chǎn)品，并使該金屬化產(chǎn)品與式XIII所示醛反應(yīng)， 并氧化形成的式XIV所示醇
10.權(quán)利要求7中的式X所示化合物，其中，R3和R4是烷基。
11.權(quán)利要求8中的式XIV所示化合物，其中，R3和R4是烷基，并且R1同權(quán)利要求1中的定義。
全文摘要
本發(fā)明公開了式I所示的化合物式中取代基的意義如下Y是氧原子或基團(tuán)NRZRRR或者R
文檔編號(hào)A01N25/30GK1120333SQ94191640
公開日1996年4月10日 申請(qǐng)日期1994年3月19日 優(yōu)先權(quán)日1993年3月29日
發(fā)明者R·多特澤, W·格拉梅諾斯, H·索特, A·哈羅伊斯, H·溫格特, E·安默曼, G·洛倫茲 申請(qǐng)人:巴斯福股份公司